- Acid-base physiology
physiologyis the study of the acids, bases and their reactions in the body. For survival, acid-base homeostasisis an absolute requirement.
The traditional approach to the study of acid-base physiology has been the
empiricapproach. The main variants are the base excessapproach and the bicarbonateapproach. The modern quantitativeapproach introduced by Peter A Stewartin 1978 [cite journal |author=Stewart P |title=Independent and dependent variables of acid-base control |journal=Respir Physiol |volume=33 |issue=1 |pages=9–26 |year= 1978|pmid=27857 |doi=10.1016/0034-5687(78)90079-8] is now emerging as the most correct approach.
pHparturition is the tendency for acids to accumulate in basic fluid compartments, and bases to accumulate in acidic compartments.
The reason is that acids become negatively
electric charged in basic fluids, since they donate a proton. On the other hand, bases become positively electric charged in acid fluids, since they receive a proton.
Since electric charge decrease the
membrane permeabilityof substances, once an acid enters a basic fluid and becomes electrically charged, then it cannot escape that compartment with ease and therefore accumulates, and vice versa with bases.
Mixed disorder of acid-base balancepH range is 7.38-7.42
* [http://www.acidbase.org Stewart's original text at acidbase.org]
* [http://umed.med.utah.edu/ms2/renal/Word%20files/h)%20Acid_Base%20Physiology.htm Overview at med.utah.edu]
* [http://www.anaesthetist.com/icu/elec/ionz/Findex.htm#acid.htm Overview at anaesthetist.com]
* [http://www.anst.uu.se/magnroos/Some%20notes%20on%20human%20acid.htm Overview at anst.uu.se]
* [http://www.acid-base.com/physiology.php Tutorial at acid-base.com]
* [http://www.anaesthesiamcq.com/AcidBaseBook/ABindex.php On-line Acid-Base Physiology text]
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