- Weber's syndrome
Weber's syndrome Classification and external resources
Midbrain cross section showing lesion
ICD-10 G46.3 ICD-9 344.89 DiseasesDB 31247 MeSH D020526
Cause and presentation
This lesion is usually unilateral and affects several structures in the midbrain including:
Structure damaged Effect substantia nigra contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body. corticospinal fibers contralateral hemiparesis and typical upper motor neuron findings corticobulbar tract difficulty with contralateral lower facial muscles and hypoglossal nerve functions oculomotor nerve fibers ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out. This leads to diplopia
It carries the name of Sir Herman David Weber, a German-born physician working in London, who described the condition in 1863. It is unrelated to Sturge-Weber syndrome or Klippel-Trenaunay-Weber syndrome.
CNS disease, Vascular disease: Cerebrovascular diseases (G45–G46 and I60–I69, 430–438) Brain ischemia/
(ischemic stroke/TIA)precerebral: Anterior spinal artery syndrome · Vertebrobasilar insufficiency (Subclavian steal syndrome)brainstem: medulla (Medial medullary syndrome, Lateral medullary syndrome) · pons (Medial pontine syndrome/Foville's, Lateral pontine syndrome/Millard-Gubler) · midbrain (Weber's, Benedikt, Claude's)General
Aneurysm Other/general Lesions of spinal cord and brain Spinal cord/
BrainstemMedulla (CN 8, 9, 10, 12)Pons (CN 5, 6, 7, 8)Midbrain (CN 3, 4)Other Cerebellum Basal ganglia Cortex Other
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