- Basal body
A basal body (sometimes basal granule or kinetosome) is an
organelleformed from a centriole, a short cylindricalarray of microtubules. It is found at the base of a eukaryotic undulipodium( ciliumor flagellum) and serves as a nucleation site for the growth of the axonememicrotubules. Centrioles, from which basal bodies are derived, act as anchoring sites for proteins that in turn anchor microtubules within centrosomes, one type of microtubule organizing center(MTOC). These microtubules provide structure and facilitate movement of vesicles and organelles within many eukaryotic cells. Basal bodies, however, are specifically the bases for cilia and flagella that extend out of the cell.
Basal bodies are derived from centrioles through a largely mysterious process. They are structurally the same, each containing a microtubules triplet 9+0 helocoidal configuration forming a hollow cylinder.
Regulation of basal body production and spatial orientation is a function of the nucleotide-binding domain of γ-tubulin (Shang et al, 2005).
Boston University Medical Histoloy: Ultrastructure of the Cell
Y. Shang, C.-C. Tsao, and M. A. Gorovsky. 2005. Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis. "J. Cell Biol." 171(6):1035-44. PMID 16344310
* - "Ultrastructure of the Cell: ciliated epithelium, cilia and basal bodies"
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См. также в других словарях:
basal body — n a minute distinctively staining cell organelle found at the base of a flagellum or cilium and resembling a centriole in structure called also basal granule, kinetosome * * * one of the cylindrical cytoplasmic bodies structurally resembling the… … Medical dictionary
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basal body — Cell Biol. a cylindrical organelle, within the cytoplasm of flagellated and ciliated cells, that contains microtubules and forms the base of a flagellum or cilium: identical in internal structure to a centriole. [1900 05] * * * … Universalium
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