Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages.cite journal | author = Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J | title = Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines | journal = Biochem. Biophys. Res. Commun. | volume = 191 | issue = 2 | pages = 535–42 | year = 1993 | pmid = 8461011 | doi = 10.1006/bbrc.1993.1251 | issn = ] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokinescite journal | author = Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J | title = The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12 | journal = Genomics | volume = 21 | issue = 2 | pages = 403–8 | year = 1994 | pmid = 7916328 | doi = 10.1006/geno.1994.1283 | issn = ] and is most closely related to CCL2 (previously called MCP1).


Further reading

citations =
*cite journal | author=Menten P, Wuyts A, Van Damme J |title=Monocyte chemotactic protein-3. |journal=Eur. Cytokine Netw. |volume=12 |issue= 4 |pages= 554–60 |year= 2002 |pmid= 11781181 |doi=
*cite journal | author=Van Damme J, Proost P, Lenaerts JP, Opdenakker G |title=Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. |journal=J. Exp. Med. |volume=176 |issue= 1 |pages= 59–65 |year= 1992 |pmid= 1613466 |doi=
*cite journal | author=Ben-Baruch A, Xu L, Young PR, "et al." |title=Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22123–8 |year= 1995 |pmid= 7545673 |doi=
*cite journal | author=Opdenakker G, Fiten P, Nys G, "et al." |title=The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. |journal=Genomics |volume=21 |issue= 2 |pages= 403–8 |year= 1994 |pmid= 7916328 |doi= 10.1006/geno.1994.1283
*cite journal | author=Minty A, Chalon P, Guillemot JC, "et al." |title=Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. |journal=Eur. Cytokine Netw. |volume=4 |issue= 2 |pages= 99–110 |year= 1993 |pmid= 8318676 |doi=
*cite journal | author=Opdenakker G, Froyen G, Fiten P, "et al." |title=Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. |journal=Biochem. Biophys. Res. Commun. |volume=191 |issue= 2 |pages= 535–42 |year= 1993 |pmid= 8461011 |doi=
*cite journal | author=Combadiere C, Ahuja SK, Van Damme J, "et al." |title=Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29671–5 |year= 1996 |pmid= 8530354 |doi=
*cite journal | author=Power CA, Clemetson JM, Clemetson KJ, Wells TN |title=Chemokine and chemokine receptor mRNA expression in human platelets. |journal=Cytokine |volume=7 |issue= 6 |pages= 479–82 |year= 1996 |pmid= 8580362 |doi= 10.1006/cyto.1995.0065
*cite journal | author=Daugherty BL, Siciliano SJ, DeMartino JA, "et al." |title=Cloning, expression, and characterization of the human eosinophil eotaxin receptor. |journal=J. Exp. Med. |volume=183 |issue= 5 |pages= 2349–54 |year= 1996 |pmid= 8642344 |doi=
*cite journal | author=Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD |title=Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. |journal=FEBS Lett. |volume=395 |issue= 2-3 |pages= 277–82 |year= 1996 |pmid= 8898111 |doi=
*cite journal | author=Meunier S, Bernassau JM, Guillemot JC, "et al." |title=Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. |journal=Biochemistry |volume=36 |issue= 15 |pages= 4412–22 |year= 1997 |pmid= 9109648 |doi= 10.1021/bi9627929
*cite journal | author=Polentarutti N, Introna M, Sozzani S, "et al." |title=Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells. |journal=Eur. Cytokine Netw. |volume=8 |issue= 3 |pages= 271–4 |year= 1997 |pmid= 9346360 |doi=
*cite journal | author=Bonini JA, Martin SK, Dralyuk F, "et al." |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249–56 |year= 1997 |pmid= 9364936 |doi=
*cite journal | author=Nibbs RJ, Wylie SM, Yang J, "et al." |title=Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32078–83 |year= 1998 |pmid= 9405404 |doi=
*cite journal | author=Wang JM, Ueda H, Howard OM, "et al." |title=HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. |journal=J. Immunol. |volume=161 |issue= 8 |pages= 4309–17 |year= 1998 |pmid= 9780207 |doi=
*cite journal | author=Albini A, Ferrini S, Benelli R, "et al." |title=HIV-1 Tat protein mimicry of chemokines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13153–8 |year= 1998 |pmid= 9789057 |doi=
*cite journal | author=Rabin RL, Park MK, Liao F, "et al." |title=Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3840–50 |year= 1999 |pmid= 10201901 |doi=
*cite journal | author=Wedemeyer J, Lorentz A, Göke M, "et al." |title=Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa. |journal=Gut |volume=44 |issue= 5 |pages= 629–35 |year= 1999 |pmid= 10205198 |doi=
*cite journal | author=Blanpain C, Migeotte I, Lee B, "et al." |title=CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. |journal=Blood |volume=94 |issue= 6 |pages= 1899–905 |year= 1999 |pmid= 10477718 |doi=
*cite journal | author=Jordan NJ, Kolios G, Abbot SE, "et al." |title=Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. |journal=J. Clin. Invest. |volume=104 |issue= 8 |pages= 1061–9 |year= 1999 |pmid= 10525044 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Chemokinrezeptor — 3D Strukturmodell des Chemokinrezeptors CXCR4 mit einem gebundenen Antagonisten Chemokinrezeptoren sind Proteine in der Oberflächenmembran von Zellen, die an Chemokine binden. Diese Bindung aktiviert den Rezeptor und löst eine Wanderung der… …   Deutsch Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Haematopoiesis — Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Haematopoiesis (from Ancient Greek: αἷμα, blood ; ποιεῖν to make ) (or hematopoiesis in the United States; sometimes also haemopoiesis or… …   Wikipedia

  • Cytokine — Cytokines (Greek cyto , cell; and kinos, movement) are small cell signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used… …   Wikipedia

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia

  • Peginterferon alfa-2a — Clinical data AHFS/ Consumer Drug Information MedlinePlus …   Wikipedia

  • Osteopontin — Secreted phosphoprotein 1 Rendering based on PDB 3CXD …   Wikipedia

  • Leukemia inhibitory factor — (cholinergic differentiation factor) PDB rendering based on 1LKI …   Wikipedia

  • Chromosome 17 (human) — Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 81 million base pairs (the building material of DNA) and represents between 2.5 and 3 % of the… …   Wikipedia

  • CCL2 — For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. Chemokine (C C motif) ligand 2 PDB rendering based on 1dok …   Wikipedia