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Section1 = Chembox Identifiers
CASNo = 317-66-8
PubChem = 1033
MeSHName = propionyl-coenzyme+A

Section2 = Chembox Properties
Formula = C24H40N7O17P3S
MolarMass = 823.599
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Section3 = Chembox Hazards
Solubility =
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Propionyl-CoA is a coenzyme A derivative of propionic acid.

Metabolism in animals


There are several different ways in which it is formed:

* It is formed as a product of beta-oxidation of odd-chain fatty acids, which occur in meat of ruminant animals.

* It is also a product of metabolism of isoleucine and valine.

* It is a product of alpha-ketobutyric acid, which in turn is a product of digestion of threonine and methionine.

Metabolic fate

In mammals, propionyl-CoA is converted to (S)-methylmalonyl-CoA by propionyl-CoA carboxylase, a biotin-dependent enzyme also requiring bicarbonate and ATP.

This product is converted to (R)-methylmalonyl-CoA by methylmalonyl-CoA racemase.

(R)-Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase, an enzyme requiring cobalamin to catalyze the carbon-carbon bond migration.

A defect in methylmalonyl-CoA mutase enzyme results in methylmalonic aciduria, a dangerous disorder that causes a lowering of blood pH.

Metabolism in plants and insects

In plants and insects propionyl-CoA is metabolized to acetate in a very different way, similar to beta oxidation.

Not all details of this pathway have been worked out, but it appears to involve formation of acrylyl-CoA, then 3-hydroxypropionyl-CoA.

This is metabolized with loss of carbon 1 of 3-hydroxypropionyl-CoA as carbon dioxide, while carbon 3 becomes carbon 1 of acetate.



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Look at other dictionaries:

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