Dopamine beta hydroxylase


Dopamine beta hydroxylase
Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Identifiers
Symbols DBH; DBM
External IDs OMIM609312 MGI94864 HomoloGene615 GeneCards: DBH Gene
EC number 1.14.17.1
RNA expression pattern
PBB GE DBH 206450 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1621 13166
Ensembl ENSG00000123454 ENSMUSG00000000889
UniProt P09172 Q3V1U4
RefSeq (mRNA) NM_000787.3 NM_138942.3
RefSeq (protein) NP_000778.3 NP_620392.2
Location (UCSC) Chr 9:
136.5 – 136.52 Mb
Chr 2:
27.02 – 27.04 Mb
PubMed search [1] [2]

Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine.

DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor.[1] It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.

DBH is inhibited by disulfiram,[2] tropolone,[3] and, most selectively, by nepicastat.[4]

See also

References

  1. ^ Rush RA, Geffen LB (1980). "Dopamine beta-hydroxylase in health and disease.". Crit Rev Clin Lab Sci. 12 (3): 241–77. doi:10.3109/10408368009108731. PMID 6998654. 
  2. ^ Goldstein M, Anagnoste B, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by Disulfiram.". Life Sci 3 (7): 763–7. doi:10.1016/0024-3205(64)90031-1. PMID 14203977. 
  3. ^ Goldstein M, Lauber E, McKeregham MR (1964). "Inhibition of dopamine-beta-hydroxylase by tropolone and other chelating agents.". Biochem Pharmacol 13 (7): 1103–6. doi:10.1016/0006-2952(64)90109-1. PMID 14201135. 
  4. ^ Stanley WC et al. (1997). "Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.". British Journal of Pharmacology 121 (8): 1803–9. doi:10.1038/sj.bjp.0701315. PMC 1564872. PMID 9283721. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1564872. 

External links