- Gastric chief cell
Chief cell H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation A fundus gland. A. Transverse section of gland. Latin exocrinocytus principalis Code TH H3.04.02.1.00031
A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a cell in the stomach that releases pepsinogen, gastric lipase and Chymosin. The cell stains basophilic upon H&E prep due to the large proportion of rough endoplasmic reticulum in its cytoplasm.
Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach. Gastrin and secretin may also act as secretagogues. 
The terms "chief cell" and "zymogenic cell" are often used without the word "gastric" to name this type of cell. However those terms can also be used to describe other cell types (for example, parathyroid chief cells.) Chief cells are also known as peptic cells.
- ^ Johnson. Gastrointestinal Physiology 6th Edition. Mosby. 2001
- Anatomy Atlases - Microscopic Anatomy, plate 01.05
- Histology at BU 22201loa - "Ultrastructure of the Cell: chief cells and enteroendocrine cell"
- Histology at BU 11304loa - "Digestive System: Alimentary Canal: fundic stomach, gastric glands, base"
- "chief cell" at Dorland's Medical Dictionary
Digestive system, physiology: gastrointestinal physiology GI tractUpper GIExocrineProcessesFluidsLower GIEndocrine/paracrineFluidsProcessesEither/bothProcesses AccessoryFluidsProcesses Abdominopelvic Human cell types / list derived primarily from endoderm ForegutCentroacinar cell · Pancreatic stellate cell Pharyngeal pouch Hindgut/cloacaUrothelial cells
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