- Thrombolytic drug
Thrombolysis is used in myocardial infarction (heart attack), thromboembolic strokes, deep vein thrombosis and pulmonary embolism to clear a blocked artery and avoid permanent damage to the perfused tissue (e.g. myocardium, brain, leg) and death. A less frequent use is to clear blocked catheters that are used in long-term medical therapy.
Thrombolytic therapy in hemorrhagic strokes is contraindicated, as its use in that situation would prolong bleeding into the intracranial space and cause further damage.
Condition Prothrombin time Partial thromboplastin time Bleeding time Platelet count Vitamin K deficiency or warfarin prolonged normal or mildly prolonged unaffected unaffected Disseminated intravascular coagulation prolonged prolonged prolonged decreased von Willebrand disease unaffected prolonged prolonged unaffected Hemophilia unaffected prolonged unaffected unaffected Aspirin unaffected unaffected prolonged unaffected Thrombocytopenia unaffected unaffected prolonged decreased Liver failure, early prolonged unaffected unaffected unaffected Liver failure, end-stage prolonged prolonged prolonged decreased Uremia unaffected unaffected prolonged unaffected Congenital afibrinogenemia prolonged prolonged prolonged unaffected Factor V deficiency prolonged prolonged unaffected unaffected Factor X deficiency as seen in amyloid purpura prolonged prolonged unaffected unaffected Glanzmann's thrombasthenia unaffected unaffected prolonged unaffected Bernard-Soulier syndrome unaffected unaffected prolonged decreased or unaffected
The thrombolytic drugs include:
These drugs are most effective if administered immediately after it has been determined they are clinically appropriate. The advantage of administration is highest within the first sixty minutes, but may extend up to six hours after the start of symptoms.
Hemorrhagic stroke is a rare but serious complication of thrombolytic therapy. If a patient has had thrombolysis before, an allergy against the thrombolytic drug may have developed (especially after streptokinase). If the symptoms are mild, the infusion is stopped and the patient is commenced on an antihistamine before infusion is recommenced. Anaphylaxis generally requires immediate cessation of thrombolysis.
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) Antiplatelet drugsADP receptor/P2Y12 inhibitorsThromboxane inhibitorsOther AnticoagulantsFactor Xa inhibitors
(with some II inhibition)Other
Non-medicinal Pharmacology: major drug groups Gastrointestinal tract/metabolism (A) Blood and blood forming organs (B) Cardiovascular system (C)Antihyperlipidemics (Statins, Fibrates, Bile acid sequestrants) Skin (D) Genitourinary system (G) Endocrine system (H) Infections and infestations (J, P, QI) Malignant disease (L01-L02) Immune disease (L03-L04) Muscles, bones, and joints (M) Brain and nervous system (N)Analgesics • Anesthetics (General, Local) • Anorectics • Anti-ADHD Agents • Antiaddictives • Anticonvulsants • Antidementia Agents • Antidepressants • Antimigraine Agents • Antiparkinson's Agents • Antipsychotics • Anxiolytics • Depressants • Entactogens • Entheogens • Euphoriants • Hallucinogens (Psychedelics, Dissociatives, Deliriants) • Hypnotics/Sedatives • Mood Stabilizers • Neuroprotectives • Nootropics • Neurotoxins • Orexigenics • Serenics • Stimulants • Wakefulness-Promoting Agents Respiratory system (R) Sensory organs (S) Other ATC (V)
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thrombolytic — Breaking up or dissolving a thrombus. SYN: thromboclastic. * * * throm·bo·lyt·ic .thräm bə lit ik adj destroying or breaking up a thrombus <a thrombolytic agent> <thrombolytic therapy> throm·bol·y·sis .thräm bäl ə səs n, pl y·ses .sēz … Medical dictionary
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