Name = Acromegaly
DiseasesDB = 114
ICD10 = ICD10|E|22|0|e|20
ICD9 = ICD9|253.0
OMIM = 102200
MedlinePlus = 000321
eMedicineSubj = med
eMedicineTopic = 27
eMedicine_mult = eMedicine2|derm|593
MeshID = D000172
Acromegaly (from Greek "akros" "extreme" or "extremities" and "megalos" "large" - extremities enlargement) is a
syndromethat results when the pituitarygland produces excess growth hormone (hGH) after epiphyseal plateclosure. A number of disorders may be affecting the pituitary to create this circumstance, although most commonly it involves a GH producing tumor derived from a distinct type of cells ( somatotrophs) and called "' pituitary adenoma.
Acromegaly most commonly affects adults in middle age, [http://www.merck.com/mmhe/sec13/ch162/ch162e.html Acromegaly and Gigantism] and can result in severe disfigurement, serious complicating conditions, and premature death if unchecked. Because of its insidious
pathogenesisand slow progression, the disease is hard to diagnose in the early stages and is frequently missed for many years, when changes in external features, especially of the face, become noticeable.
Acromegaly is often also associated with
Features that result from high level of hGH or expanding tumor include:
* Soft tissue swelling visibly resulting in enlargement of the hands, feet, nose, lips and ears, and a general thickening of the skin
* Soft tissue swelling of internal organs, notably the heart with attendant weaking of its muscularity, and the kidneys, also the vocal cords resulting in a characteristic thick, deep voice and slowing of speech
* Generalized expansion of the skull at the fontanelle
* Pronounced brow protrusion, often with ocular distension
* Pronounced lower jaw protrusion with attendant
macroglossiaand teeth gapping
Arthritisand carpal tunnel syndrome
* Enlarged heart
* Compression of the
optic chiasmleading to loss of vision in the outer visual fields (typically bitemporal hemianopia)
* Increased palmar sweating and
sebumproduction over the face ( seborrhea) are clinical indicators of active growth hormone (GH) producing pituitary tumors. These symptoms can also be used to monitor the activity of the tumor after surgery although biochemical monitoring is confirmatory.
In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a benign tumor of the pituitary gland, called an adenoma. These tumors produce excess growth hormones and, as they expand, compress surrounding brain tissues, such as the optic nerves. This expansion causes the headaches and visual disturbances that often accompany acromegaly. In addition, compression of the surrounding normal pituitary tissue can alter production of other
hormones, leading to changes in menstruation and breast discharge in women and impotencein men because of reduced testosteroneproduction.
There is a marked variation in rates of GH production and the aggressiveness of the tumor. Some adenomas grow slowly and symptoms of growth hormone excess are often not noticed for many years. Other adenomas grow rapidly and invade surrounding brain areas or the sinuses, which are located near the pituitary. In general, younger patients tend to have more aggressive tumors.
Most pituitary tumors arise spontaneously and are not genetically inherited. Many pituitary tumors arise from a genetic alteration in a single pituitary cell which leads to increased cell division and tumor formation. This genetic change, or
mutation, is not present at birth, but is acquired during life. The mutation occurs in a gene that regulates the transmission of chemical signals within pituitary cells; it permanently switches on the signal that tells the cell to divide and secrete growth hormones. The events within the cell that cause disordered pituitary cell growthand growth hormone oversecretion currently are the subject of intensive research.
In a few patients, acromegaly is caused not by pituitary tumors but by
tumors of the pancreas, lungs, and adrenal glands. These tumors also lead to an excess of GH, either because they produce GH themselves or, more frequently, because they produce GHRH, the hormone that stimulates the pituitary to make GH. In these patients, the excess GHRH can be measured in the blood and establishes that the cause of the acromegaly is not due to a pituitary defect. When these non-pituitary tumors are surgically removed, GH levels fall and the symptoms of acromegaly improve.
In patients with GHRH-producing, non-pituitary tumors, the pituitary still may be enlarged and may be mistaken for a tumor. Therefore, it is important that physicians carefully analyze all "pituitary tumors" removed from patients with acromegaly in order not to overlook the possibility that a tumor elsewhere in the body is causing the disorder.
If acromegaly is suspected,
medical imagingand medical laboratoryinvestigations are generally used together to confirm or rule out the presence of this condition.
IGF1provides the most sensitive and useful lab test for the diagnosis of acromegaly. A single value of the Growth hormone (GH) is not useful in view of its pulsatality (levels in the blood vary greatly even in healthy individuals). GH levels taken 2 hours after a 75 or 100 gram glucose tolerance testare helpful in the diagnosis: GH levels are suppressed below 1 μg/L in normal people, and levels higher than this cutoff are confirmatory of acromegaly.
* Other pituitary hormones have to be assessed to address the secretory effects of the tumor as well as the mass effect of the tumor on the normal pituitary gland. They include TSH (thyroid stimulating hormone), gonadotropic hormones (FSH,LH), ACTH (adrenocorticotropic hormone),
*An MRI of the brain focusing on the
sella turcicaafter gadoliniumadministration allows for clear delineation of the pituitary and the hypothalamus and the location of the tumor.
The goals of treatment are to reduce GH production to normal levels, to relieve the pressure that the growing pituitary tumor exerts on the surrounding brain areas, to preserve normal pituitary function, and to reverse or ameliorate the symptoms of acromegaly. Currently, treatment options include surgical removal of the tumor, drug therapy, and
radiation therapyof the pituitary.
*Surgery is a rapid and effective treatment, of which there are two alternative methods. The first method, a procedure known as Endonasal Transphenoidal surgery, involves the surgeon reaching the pituitary through an incision in the nasal cavity wall. The wall is reached by passing through the nostrils with microsurgical instruments. The second method is Transsphenoidal surgery during which an incision is made into the gum beneath the upper lip. Further incisions are made to cut through the septum to reach the nasal cavity, where the pituitary is located. Endonasal Transphenoidal surgery is a less invasive procedure with a shorter recovery time than the older method of Transphenoidal surgery, and the likelihood of removing the entire tumor is greater with reduced side-effects. Consequently, Endonasal Transphenoidal surgery is often used as a first option, with Transphenoidal and other treatments, such as, medicinal therapy or radiostatic neurosurgery being used to reduce the remaining adverse effects of the remaining tumor.
These procedures normally relieve the pressure on the surrounding brain regions and lead to a lowering of GH levels. If the surgery is successful, facial appearance and soft tissue swelling improve within a few days. Surgery is most successful in patients with blood GH levels below 40 ng/ml before the operation and with pituitary tumors no larger than 10 mm in diameter. Success depends on the skill and experience of the surgeon. The success rate also depends on what level of GH is defined as a cure. The best measure of surgical success is normalization of GH and IGF-1 levels. Ideally, GH should be less than 2 ng/ml after an oral glucose load. A review of GH levels in 1,360 patients worldwide immediately after surgery revealed that 60 percent had random GH levels below 5 ng/ml. Complications of surgery may include
cerebrospinal fluidleaks, meningitis, or damage to the surrounding normal pituitary tissue, requiring lifelong pituitary hormone replacement.
Even when surgery is successful and hormone levels return to normal, patients must be carefully monitored for years for possible recurrence. More commonly, hormone levels may improve, but not return completely to normal. These patients may then require additional treatment, usually with medications.
*Two medications currently are used to treat acromegaly. These drugs reduce both GH secretion and tumor size. Medical therapy is sometimes used to shrink large tumors before surgery.
Bromocriptine(Parlodel) in divided doses of about 20 mg daily reduces GH secretion from some pituitary tumors. Side effects include gastrointestinal upset, nausea, vomiting, light-headedness when standing, and nasal congestion. These side effects can be reduced or eliminated if medication is started at a very low dose at bedtime, taken with food, and gradually increased to the full therapeutic dose. Because bromocriptine can be taken orally, it is an attractive choice as primary drug or in combination with other treatments. However, bromocriptine lowers GH and IGF-1levels and reduces tumor size in fewer than half of patients with acromegaly. Some patients report improvement in their symptoms although their GH and IGF-1 levels still are elevated.
The second medication used to treat acromegaly is
octreotide(Sandostatin) and lanreotide(Somatuline). Both are synthetic forms of a brain hormone, somatostatin, that stops GH production. The long-acting forms of these drugs must be injected every 2 to 4 weeks for effective treatment. Most patients with acromegaly respond to this medication. In many patients, GH levels fall within one hour and headaches improve within minutes after the injection. Several studies have shown that octreotide and lanreotide are effective for long-term treatment. Octreotide and lanreotide have also been used successfully to treat patients with acromegaly caused by non-pituitary tumors.
Because octreotide inhibits gastrointestinal and pancreatic function, long-term use causes digestive problems such as loose stools, nausea, and gas in one third of patients. In addition, approximately 25 percent of patients develop
gallstones, which are usually asymptomatic. In rare cases, octreotide treatment can cause diabetes. On the other hand, scientists have found that in some acromegaly patients who already have diabetes, octreotide can reduce the need for insulinand improve blood sugarcontrol.
*The latest development in the medical treatment of acromegaly is the use of growth hormone receptor antagonists. The only available member of this family is pegvisomant (Somavert). By blocking the action of the endogenous growth hormone molecules, this compound is able to control disease activity of acromegaly in virtually all patients. Pegvisomant has to be administered subcutaneously by daily injections. Combinations of long-acting somatostatin analogues and weekly injections of pegvisomant seem to be equally effective as daily injections of pegvisomant.
*Radiation therapy has been used both as a primary treatment and combined with surgery or drugs. It is usually reserved for patients who have tumor remaining after surgery. These patients often also receive medication to lower GH levels. Radiation therapy is given in divided doses over four to six weeks. This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement. Radiation therapy causes a gradual loss of production of other pituitary hormones with time. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments.
No single treatment is effective for all patients. Treatment should be individualized depending on patient characteristics, such as age and tumor size. If the tumor has not yet invaded surrounding brain tissues, removal of the pituitary adenoma by an experienced neurosurgeon is usually the first choice. After surgery, a patient must be monitored for a long time for increasing GH levels. If surgery does not normalize hormone levels or a relapse occurs, a doctor will usually begin additional drug therapy. The first choice should be bromocriptine because it is easy to administer; octreotide is the second alternative. With both medications, long-term therapy is necessary because their withdrawal can lead to rising GH levels and tumor re-expansion. Radiation therapy is generally used for patients whose tumors are not completely removed by surgery; for patients who are not good candidates for surgery because of other health problems; and for patients who do not respond adequately to surgery and medication.
Pituitary gigantism in children
This condition of growth hormone excess is rare in children and is referred to as pituitary gigantism, because the excessive growth hormone produces excessive growth of bones and the child can achieve excessive height; from seven to nine feet in stature by adulthood if left untreated. As an affected child becomes an adult, many of the adult problems can gradually develop. The distinction between gigantism (occurring in children) and acromegaly (occurring in adults) can be made by the occurrence of the adenoma in relation to the closure of the epiphyses. If elevated growth hormone levels occur before the closure of the epiphyses (i.e. in prepubertal children), then gigantism ensues. If it occurs after the closure of the epiphyses (i.e., in adults) then acromegaly ensues.
Famous patients, all but one (
Maurice Tillet) standing in excess of 2.00 metres (6.6 feet):
Richard KielFact|date=September 2008 ('Jaws' in the James Bondmovies), 7'1.5" tall
Ted CassidyFact|date=September 2008 (known for playing Lurch in "The Addams Family" TV series)
Jack EarleFact|date=September 2008 7 ft 7½in
Carel StruyckenFact|date=September 2008 (known for playing Lurch in the Addams Familymovies, and for his other giant roles), 7' tall. Had successful pituitary surgery in 1993.
Matthew McGroryFact|date=September 2008 (listed in the Guinness Book of World Recordsfor having the largest feet - size 29 1/2), 7'6" tall (died at the age of 32)
Rondo Hatton,Fact|date=September 2008 who allegedly developed the syndrome as a result of exposure to a chemical agent while on combat duty with the United States military, where he had originally planned a careerFact|date=July 2008.
* Actor Harry Wilson,Fact|date=September 2008 who, in addition to an extensive career doing character parts in almost 200 films, starting at the very end of the silent era, also had an additional career as a stand-in for
Wallace Beeryfor approximately 25 years.
* Wrestler and actor
André the Giant,citeweb|title=Andre the Giant: Bio|work=WWE.com|url=http://www.wwe.com/superstars/halloffame/andrethegiant/bio/|accessdate=2007-10-16] [cite web|url=http://www.andrethegiant.com/|title=André the Giant official website.|accessdate=2007-07-08] 7' tall after back surgery; his original wrestling stats listed him at 7'4". He died at the age of 46, when most sufferers weren't expected to live past the age of 40. (He chose not to be treated and died from the disease)
Paul WightFact|date=September 2008 ("The Big Show"), had surgery on his pituitary gland in the 1990s to fix the condition, his height peaking at 7'1" tall
Maurice Tillet,Fact|date=September 2008 aka "The French Angel" ( 1903?- August 4, 1954 ), 5'10", 276 Ibs.
Paul Olafsson,Fact|date=September 2008 aka "The Swedish Angel"
* Wrestler and mixed martial artist Paulo César da SilvaFact|date=September 2008 ("Giant Silva"), 7'5" tall
* Wrestler Jorge GonzalezFact|date=September 2008 ("El Gigante"), 7'6" tall
* Former NBA player
Gheorghe MureşanFact|date=September 2008 (star of My Giant), 7'7" tall
* Aspiring basketball player
Sun Ming Ming,Fact|date=September 2008 7'9" tall
* Makeup artist
Kevyn AucoinFact|date=September 2008
* Life coach, writer, and professional speaker
Tony Robbins,Fact|date=September 2008 6'7" tall
* Kickboxer and mixed martial artist
Choi Hong Man,Fact|date=September 2008 7'2" tall
Jon Danzig, BBCinvestigative journalist [http://news.independent.co.uk/health/article3088061.ece]
* UNC-Asheville Basketball player
Kenny George,Fact|date=September 2008 7'7" tall
It has been suggested that the character 'Punch' from
Punch and Judywas originally a caricature of an Acromegaly sufferer. [ [http://news.bbc.co.uk/1/hi/england/derbyshire/5315432.stm BBC News report on Punch and Acromegaly] ]
Paul Benedicthad an arrested case of acromegaly. After his performance in a stage production, a member of the audience came backstage and introduced himself as an endocrinologist; he had diagnosed Benedict's condition during the performance and was ultimately able to treat him before the disease reached its later stages.Fact|date=August 2007
The 1944 film "
The Monster Maker" erroneously presents the concept of "acromegaly germs" and of the swelling and bone distensions caused by the syndrome as being reversible.
* [http://www.acromegaly.org acromegaly.org A satellite site of the Pituitary Network Association]
* [http://www.medstudents.com.br/endoc/endoc8.htm Acromegaly and Gigantism (a very comprehensive article)]
* [http://www.medstudents.com.br/image/endoc/imgend9.htm Acromegaly and Gigantism (Image of a patient with macroglossia - enlargement of the tongue)]
* [http://news.bbc.co.uk/1/hi/health/7246419.stm "Handshake diagnosed brain tumour"] at
* [http://www.niddk.nih.gov/health/endo/pubs/acro/acro.htm Endocrine and Metabolic Diseases Information Service]
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Look at other dictionaries:
Acromegaly — Ac ro*meg a*ly, n. [NL. acromegalia, fr. Gr. a kron point, peak + ?, ?, big.] (Med.) Chronic enlargement of the extremities and face. [1913 Webster] … The Collaborative International Dictionary of English
acromegaly — (n.) gigantism due to activity of pituitary after normal growth has ceased, 1886, from Fr. acromégalie, from medical L. acromegalia, from Gk. akron extremity (see ACRID (Cf. acrid)) + megas great (fem. megale; see MICKLE (Cf. mickle)). Said in… … Etymology dictionary
acromegaly — [ak΄rō meg′ə lē] n. [Fr acromégalie: see ACRO & MEGALO ] a disease in which there is enlargement of the bones of the head, hands, and feet, resulting from an overproduction of growth hormone that is caused, usually, by a tumor in the pituitary… … English World dictionary
acromegaly — acromegalic /ak roh meuh gal ik/, adj. /ak reuh meg euh lee/, n. Pathol. a chronic disease characterized by enlargement of the bones of the head, the soft parts of the feet and hands, and sometimes other structures, due to excessive secretion of… … Universalium
Acromegaly — Condition due to the production of too much growth hormone by the pituitary gland after the end of adolescence. When there is secretion of too much growth hormone before the end of adolescence, gigantism results. People with pituitary gigantism… … Medical dictionary
acromegaly — A condition in which the pituitary gland makes too much growth hormone after normal growth of the skeleton is finished. This causes the bones of the hands, feet, head, and face to grow larger than normal. Acromegaly can be caused by a pituitary… … English dictionary of cancer terms
acromegaly — noun Etymology: International Scientific Vocabulary Date: 1889 a disorder caused by excessive production of growth hormone by the pituitary gland and marked especially by progressive enlargement of hands, feet, and face • acromegalic adjective … New Collegiate Dictionary
acromegaly — Enlargement of the extremities of the body as a result of the overproduction of growth hormone (somatotropin), eg. by a pituitary tumour … Dictionary of molecular biology
acromegaly — noun A chronic disease marked by enlargement of the bones of the extremities, face, and jaw that is caused by over activity of the pituitary gland. Syn … Wiktionary
acromegaly — n. (Pathology) abnormal condition causing enlargement of the bones (in the hands, feet and head) … English contemporary dictionary