Interleukin 27

protein
Name = Interleukin 27
caption =


width =
HGNCid = 19157
Symbol = IL27
AltSymbols = , IL30, p28
EntrezGene = 246778
OMIM = 608273
RefSeq = NM_145659
UniProt = Q6P676
PDB =
ECnumber =
Chromosome = 16
Arm = p
Band = 11
LocusSupplementaryData =protein
Name = Interleukin 27B
caption =


width =
HGNCid = 3129
Symbol = IL27B
AltSymbols = EBI3
EntrezGene =
OMIM = 605816
RefSeq =
UniProt = Q14213
PDB =
ECnumber =
Chromosome =
Arm =
Band =
LocusSupplementaryData =

Overview

Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30). [F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.] IL-27 is produced by antigen-presenting cells. [ [http://www.ncbi.nlm.nih.gov/pubmed/14657353 IL-27 regulates IL-12 responsiveness of naive CD4 [Proc Natl Acad Sci U S A. 2003 - PubMed Result ] ] IL-27 plays an important function in regulating the activity of B and T lymphocytes. [F. Larousserie et al., Differential Effects of IL-27 on Human B Cell Subsets. Journal of Immunology, 2006, Volume 176, pages 5890-5897.] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27. [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157]

References