Immediate early gene


Immediate early gene

Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first round of response to stimuli, before any new proteins are synthesized. Thus IEGs are distinct from "late response" genes, which can only be activated later following the synthesis of early response gene products. Thus IEGs have been called the "gateway to the genomic response". The term can describe viral regulatory proteins that are synthesized following viral infection of a host cell, or cellular proteins that are made immediately following stimulation of a resting cell by extracellular signals.

About 40 cellular IEGs have been identified so far. The earliest known and best characterized include "c-fos", "c-myc" and "c-jun", genes that were found to be homologous to retroviral oncogenes. Thus IEGs are well known as early regulators of cell growth and differentiation signals. However, other findings suggest roles for IEGs in many other cellular processes.

In their role as "gateways to genomic response", many IEG products are naturally transcription factors or other DNA-binding proteins. However, other important classes of IEG products include secreted proteins, cytoskeletal proteins, and receptor subunits.

Some IEGs (for example zif268) have been implicated in learning and memory and long-term potentiation. [cite journal |author=Davis S, Bozon B, Laroche S |title=How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning? |journal=Behav Brain Res |volume=142 |issue=1-2 |pages=17–30 |year=2003 |pmid=12798262 |doi=10.1016/S0166-4328(02)00421-7]

External links

* [http://www.nida.nih.gov/pdf/monographs/125.pdf Activation of Immediate Early Genes by Drugs of Abuse] a monograph published by the National Institute on Drug Abuse
*MeshName|Immediate-Early+Genes
*MeshName|Immediate-Early+Proteins

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Immediate early gene — Ein Immediate early gene (kurz: IEG, zu deutsch etwa unmittelbares frühes Gen) ist ein Gen, das innerhalb weniger Minuten nach der Stimulation einer Zelle transkribiert wird. Die Transkription dieser Gene ist nur vorübergehend und endet bereits… …   Deutsch Wikipedia

  • immediate early gene — A viral gene that is expressed promptly after infection …   Glossary of Biotechnology

  • immediate early gene — Class of genes whose expression is low or undetectable in quiescent cells, but whose transcription is activated within minutes after extracellular stimulation such as addition of a growth factor. c fos and c myc proto oncogenes were among the… …   Dictionary of molecular biology

  • Early history of private equity — The early history of private equity relates to one of the major periods in the history of private equity and venture capital. Within the broader private equity industry, two distinct sub industries, leveraged buyouts and venture capital… …   Wikipedia

  • Gene Derricotte — Infobox NFL player Name=Gene Derricotte team= ImageWidth= Caption= status= import= Position=HB/PR/KR number=41 College=Michigan DateOfBirth= Birthplace= DateOfDeath= Deathplace= Height ft=5 Height in=10 Weight lbs=178 AFLDraftedYear=… …   Wikipedia

  • Glossary of gene expression terms — See also: gene expression, List of Glossaries, List of Natural Sciences Glossaries A*Activator protein that binds to an enhancer (or activator binding region) and activates transcription from nearby promoter.*A DNA a form of DNA found at low… …   Wikipedia

  • ID3 (gene) — Inhibitor of DNA binding 3, dominant negative helix loop helix protein, also known as ID3, is a human gene.cite web | title = Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix loop helix protein| url =… …   Wikipedia

  • NOV (gene) — Nephroblastoma overexpressed gene Identifiers Symbols NOV; CCN3; IGFBP9 External IDs …   Wikipedia

  • GEM (gene) — GTP binding protein overexpressed in skeletal muscle, also known as GEM, is a human gene.cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • ERF (gene) — Ets2 repressor factor, also known as ERF, is a human gene.cite web | title = Entrez Gene: ERF Ets2 repressor factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2077| accessdate = ] PBB Summary section… …   Wikipedia