- Ulf von Euler
name = Ulf von Euler
image_width = 150px
caption = Ulf von Euler, a Nobel laureat puic|
February 7, 1905
March 9, 1983(age 78)
Neurotransmitter, Norepinephrine, Prostaglandin
Nobel Prize in Physiology or Medicine(1970)
Ulf Svante von Euler (
February 7, 1905– March 9, 1983) was a Swedish physiologist and pharmacologist. He won a Nobel Prize in Physiology or Medicinein 1970 for his work on neurotransmitters.
Ulf S. von Euler was born in
Stockholm, the son of two noted scientists, Dr. Hans von Euler-Chelpin, a professor of chemistry, and Dr. Astrid Cleve, a professor of botanyand geology. His father was German and the recipient of Nobel Prize for Chemistryin 1929, and his maternal grandfather was Per Teodor Cleve, Professor of Chemistryat the Uppsala University, and the discoverer of the chemical elements thuliumand holmium.
Enjoying such a privileged family environment in science, education and research, it is not surprising that young Ulf would become a scientist, too, so he went to study
medicineat the Karolinska Institutein 1922. At Karolinska, he worked under Robin Fåhraeusin blood sedimentation and rheologyand did research work on the pathophysiologyof vasoconstriction. He presented his doctoral thesis in 1930, and was appointed as Assistant Professor in Pharmacology in the same year, with the support of G. Liljestrand. From 1930 to 1931 von Ulf got a Rochester Fellowship to do his post-doctoral studies abroad. He studied in Englandwith Sir Henry Dalein Londonand with I. de Burgh Daly in Birmingham, and then proceeded to the continent, studying with Corneille Heymans in Ghent, Belgiumand with Gustav Embdenin Frankfurt, Germany. Von Euler liked to travel, so he also worked and learned biophysicswith Archibald Vivian Hill, again in London in 1934, and neuromuscular transmissionwith G. L. Brown in 1938. From 1946 to 1947, he worked with Eduardo Braun-Menéndezin the Instituto de Biología y Medicina Experimentalin Buenos Aires, which was founded by Bernardo Houssay. His unerring instinct to work with important scientific leaders and fields was to be proved by the fact that Dale, Heymans, Hill and Houssay went to receive the Nobel prize in physiology or medicine.
From 1930 to 1957, von Euler was married to Jane Sodenstierna. They had four children: Hans Leo, scientist administrator (retired) at the National Institutes of Health, Bethesda, Maryland, U.S.A.; Johan Christopher, anesthesiologist, Serafimer Hospital, Stockholm; Ursula Katarina, Ph.D., curator at The Royal Collections, The Royal Court, Stockholm, Sweden; and Marie Jane, Chemical Engineer, Melbourne, Australia. In 1958, von Euler married Dagmar Cronstedt, who had worked for Germany during the second world war at
His short stay as a postdoctoral student in Dale's laboratory was very fruitful: in 1931 he discovered with
John H. Gadduman important autopharmacological principle, substance P. After returning to Stockholm, von Euler pursued further this line of research, and successively discovered four other important endogenous active substances, prostaglandin, vesiglandin(1935), piperidine(1942) and noradrenaline(1946).
In 1939 von Euler was appointed Full Professor of Physiology at the Karolinska Institute, where he remained until 1971. His early collaboration with Liljestrand had led to an important discovery, which was named the
Euler-Liljestrand mechanism(a physiological arterial shuntin response to the decrease in local oxygenation of the lungs).
From 1946 on, however, when noradrenaline was discovered, von Euler devoted most of his research work to this area. He and his group studied thoroughly its distribution and fate in
biological tissues and the in the nervous systemin physiological and pathological conditions, and found that noradrenaline was produced and stored in nerve synaptic terminals in intracellular vesicles, a key discovery which changed dramatically the course of many researches in the field. In 1970 he was distinguished with the Nobel Prize for his work, jointly with Sir Bernard Katzand Julius Axelrod. Since 1953 he was very active in the Nobel Foundation, being a member of the Nobel Committee for Physiology or Medicine and Chairman of the Board since 1965. He also served as Vice-President of the International Union of Physiological Sciencesfrom 1965 to 1971. Among the many honorary titles and prizes he received in addition to the Nobel, were the Gairdner Prize(1961), the Jahre Prize(1965), the Stouffer Prize(1967), the Carl Ludwig Medaille(1953), the Schmiedeberg Plaquette(1969), La Madonnina(1970), many honorary doctorates from universities around the world, and the membership to several erudite, medical and scientific societies.
Dr. von Euler died on March 9th, 1983.
* Sabbatini, R.M.E.: [http://www.cerebromente.org.br/n17/history/neurons5_i.htm Neurons and synapses. The history of its discovery IV. Chemical transmission] . "Brain & Mind", 2004.
* [http://nobelprize.org/medicine/laureates/1970/euler-bio.html Ulf von Euler - Biography] . Nobel Foundation.
* [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1403098 1931 Substance P Paper]
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