HMG-CoA

HMG-CoA

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ImageFile=HMG coenzyme A.svg
ImageSize=300px
IUPACName=(9R,21S)-1- [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl] -3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide
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Section1= Chembox Identifiers
CASNo=1553-55-5
PubChem=84
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MeSHName=HMG-CoA
Section2= Chembox Properties
Formula=C27H44N7O20P3S
MolarMass=911.661 g/mol
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Section3= Chembox Hazards
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HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the Mevalonate pathway. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase.

HMG-CoA reductase converts it into mevalonic acid.

Also, HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.


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