Hepatocyte growth factor


Hepatocyte growth factor

Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing. [cite book | title=Proteoglycans: structure, biology and molecular interactions | author=Gallagher, J.T., Lyon, M. | chapter=Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens | editor=Iozzo, M, V. | year=2000 | publisher=Marcel Dekker Inc. New York, New York | pages=27-59]

PBB_Summary
section_title =
summary_text = Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [cite web | title = Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3082| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakamura T |title=Structure and function of hepatocyte growth factor. |journal=Prog. Growth Factor Res. |volume=3 |issue= 1 |pages= 67–85 |year= 1992 |pmid= 1838014 |doi=
*cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924–40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001
*cite journal | author=Funakoshi H, Nakamura T |title=Hepatocyte growth factor: from diagnosis to clinical applications. |journal=Clin. Chim. Acta |volume=327 |issue= 1-2 |pages= 1–23 |year= 2003 |pmid= 12482615 |doi=
*cite journal | author=Skibinski G |title=The role of hepatocyte growth factor/c-met interactions in the immune system. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=51 |issue= 5 |pages= 277–82 |year= 2004 |pmid= 14626426 |doi=
*cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776–84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530
*cite journal | author=Hurle RA, Davies G, Parr C, "et al." |title=Hepatocyte growth factor/scatter factor and prostate cancer: a review. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1339–49 |year= 2006 |pmid= 16136515 |doi=
*cite journal | author=Kemp LE, Mulloy B, Gherardi E |title=Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 414–7 |year= 2006 |pmid= 16709175 |doi= 10.1042/BST0340414

ee also

* growth factor
* hepatocyte growth factor receptor (HGFR)

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • hepatocyte growth factor — (HGF) a potent mitogen and inducer of hepatocyte proliferation, produced by nonparenchymal cells in the liver and by mesenchymal cells in many other organs. Called also scatter f …   Medical dictionary

  • hepatocyte growth factor — Polypeptide mitogen originally shown to cause cell division in hepatocytes. In the liver, the main sources of HGF are non parenchymal cells. It is now clear that HGF is a mitogen for a number of cell types and it is found in many cells outside… …   Dictionary of molecular biology

  • Growth factor — The term growth factor refers to a naturally occurring protein capable of stimulating cellular growth, [DorlandsDict|three/000038554|growth factor] proliferation and cellular differentiation. Growth factors are important for regulating a variety… …   Wikipedia

  • Growth factor — Dieser Artikel behandelt Wachstumsfaktor als Begriff aus der Biologie. Das Wort wird außerdem verwendet bei der mathematischen Untersuchung von Wachstumsprozessen (siehe Wachstumsfaktor (Mathematik)) Als Wachstumsfaktoren werden Proteine… …   Deutsch Wikipedia

  • Hepatocyte nuclear factor 4 alpha — Hepatocyte nuclear factor 4, alpha PDB rendering based on 1m7w …   Wikipedia

  • Transforming growth factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Transforming Growth Factor — Der Transforming Growth Factor (Abk. TGF, deut. Transformierender Wachstumsfaktor) gehört zu den Zytokinen zählenden Signalmolekülen. Sie sind namensgebend für die TGF Signalwege. TGF spielen eine sehr wichtige Rolle bei der embryonalen… …   Deutsch Wikipedia

  • Nerve growth factor — (beta polypeptide) Rendering of NGF from PDB 1SG1 …   Wikipedia

  • Epidermal growth factor receptor — This article is about a cell surface receptor. For estimated measure of kidney function (eGFR), see Glomerular filtration rate. Epidermal growth factor receptor …   Wikipedia

  • Low-affinity nerve growth factor receptor — P75 redirects here. For the New Testament manuscript, see Papyrus 75. For Pentium processor at 75 MHz, see Intel P5 (microarchitecture). Nerve growth factor receptor PDB rendering based on 1sg1 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.