- Vascular resistance
Vascular resistance is a term used to define the resistance to flow that must be overcome to push
bloodthrough the circulatory system. The resistance offered by the peripheral circulation is known as the systemic vascular resistance (SVR), while the resistance offered by the vasculature of the lungs is known as the pulmonary vascular resistance (PVR). The systemic vascular resistance may also be referred to as the total peripheral resistance. Vasoconstriction (i.e., decrease in blood vessel diameter) increases SVR, whereas vasodilation (increase in diameter) decreases SVR.
Units for measuring vascular resistance are dyn·s·cm-5 or pascal seconds per cubic metre (Pa·s/m³). Pediatric cardiologists use hybrid reference units (HRU), also known as Wood units, as they were introduced by Dr. Paul Wood. To convert from Wood units to MPa·s/m3 you must multiply by 8, or to dyn·s·cm-5 you must multiply by 80.
Calculation of resistance
The basic tenet of calculating resistance is that flow is equal to driving pressure divided by resistance.
The pulmonary vascular resistance can therefore be calculated in units of dyn·s·cm-5 as
where the pressures are measured in units of millimetres of mercury (
mmHg) and the cardiac output is measured in units of litres per minute(L/min).
Determinants of vascular resistance
The major determinant of vascular resistance is "small arteriolar" (known as resistance
arterioles) tone. These vessels are from 450 µm down to 100 µm in diameter. (As a comparison, the diameter of a capillaryis about 3 to 4 µm.)
Another determinant of vascular resistance is the "pre-capillary arterioles". These arterioles are less than 100 µm in diameter. They are sometimes known as autoregulatory vessels.
Regulation of vascular resistance
There are many factors that alter the vascular resistance. Many of the
platelet-derived substances, including serotonin, are vasodilatory when the endotheliumis intact and are vasoconstrictive when the endothelium is damaged.
Cholinergic stimulation causes release of
endothelium-derived relaxing factor(EDRF) (later it was discovered that EDRF was nitric oxide) from intact endothelium, causing vasodilatation. If the endothelium is damaged, cholinergic stimulation causes vasoconstriction.
Role of adenosine
Adenosineprobably doesn't play a role in maintaining the vascular resistance in the resting state. However, it causes vasodilatation and decreased vascular resistance during hypoxia. Adenosine is formed in the myocardial cells during hypoxia, ischemia, or vigorous work, due to the breakdown of high-energy phosphate compounds (e.g., adenosine monophosphate, AMP). Most of the adenosine that is produced leaves the cell and acts as a direct vasodilator on the vascular wall. "Because adenosine acts as a direct vasodilator, it is not dependent on an intact endothelium to cause vasodilatation."
Adenosine causes vasodilatation in the small and medium sized resistance arterioles (less than 100 µm in diameter). When adenosine is administered it can cause a coronary steal phenomenon, where the vessels in healthy tissue dilate as much as the ischemic tissue and more blood is shunted away from the ischemic tissue that needs it most. This is the principle behind adenosine stress testing.
Adenosine is quickly broken down by
adenosine deaminase, which is present in red cells and the vessel wall.
Coronary vascular resistance
The regulation of tone in the coronary arteries is a complex subject. There are a number of mechanisms for regulating coronary vascular tone, including metabolic demands (ie: hypoxia), neurologic control, and endothelial factors (ie: EDRF,
Local metabolic control (based on metabolic demand) is the most important mechanism of control of coronary flow. Decreased tissue oxygen content and increased tissue CO2 content act as vasodilators Acidosis acts as a direct coronary vasodilator and also potentiates the actions of
adenosineon the coronary vasculature.
1. Grossman W, Baim D. "Grossman's" "Cardiac Catheterization, Angiography,and Intervention", Sixth Edition. Page 172, Tabe 8.1 ISBN 0-683-30741-X
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