Prothrombin complex concentrate

Prothrombin Complex Concentrate (PCC) (trade name Beriplex or Octaplex^[1]) is a combination of blood clotting factors II, VII, IX and X, as well as protein C and S.^[1] It reverses the effect of warfarin (a coumarin anti-coagulant) and is used in cases of significant bleeding in patients with a coagulopathy (INR > 8.0, prolonged prothrombin time, raised d-dimer). Examples include gastrointestinal haemorrhage or intracranial haemorrhage.

PCC is effective but expensive. In the UK is prescribed in discussion with a senior haematologist.

See also

• Beriplex
• Cofact

References

1. ^ ^{a b} FASS.se (Farmaceutiska Specialiteter i Sverige - the Swedish official drug catalog) > Ocplex Last updated: 2009–09–03

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.v · Categories: Blood products Coagulation system Blood and blood forming organ drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Urszula Radwańska Tandem pore domain potassium channel Look at other dictionaries: prothrombin complex concentrate — (PCC) factor IX complex …   Medical dictionary activated prothrombin complex concentrate — (APCC) anti inhibitor coagulant complex …   Medical dictionary anti-inhibitor coagulant complex — (AICC) a concentrated fraction from pooled human plasma, which includes vitamin K–dependent coagulation factors (factors II, VII, IX, X), factors of the kinin generating system, and factor VIII coagulant antigen. It is administered… …   Medical dictionary Thrombin — Coagulation factor II (thrombin) The structure of human thrombin in complex with the inhibitor hirudin.[1] …   Wikipedia Coagulation — This article is about blood clotting. For other meanings see Coagulation (disambiguation). Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel,… …   Wikipedia CSL Limited — Type Public (ASX: CSL) Industry medicine Founded 1994 (privatised), 1916 (government department) Headquarters Parkville, Melbourne, Vic …   Wikipedia Warfarin — This article is about the drug with the brandname Coumadin. For the anticoagulant rodenticide poisons often called coumarins or coumadins , see 4 hydroxycoumarins. Warfarin …   Wikipedia PCC — may stand for: Contents 1 Biology and chemistry 2 Medicine 3 Organizations and companies 4 Colleges 5 …   Wikipedia Dabigatran — étéxilate de dabigatran Général Nom IUPAC 3 {[(2 {[(4 {N [(hexyloxy)carbonyl]carbamimidoyl} phényl)amino]méthyl} 1 méthyl 1H benzimidazol 5 yl)carbonyl](2 pyridinyl)amino}propano …   Wikipédia en Français PCC — Pasteur Culture Collection; patient centered care; percutaneous cecostomy; peripheral cholangiocarcinoma; pheochromocytoma; phosphate carrier compound; plasma catecholamine concentration; platinum containing compound; pneumatosis cystoides coli;… …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”