Tetanolysin


Tetanolysin

Tetanolysin is a toxin produced by "Clostridium tetani" bacteria.

"Clostridium tetani", the causative agent of the disease tetanus, produces two exotoxins, tetanolysin and tetanospasmin. The function of tetanolysin is not known with certainty but there is data that suggests tetanolysin may contribute to the pathogenesis of tetanus.

Tetanolysin belongs to a family of protein toxins known as cytolysins which bind to cholesterol. Cytolysins form pores in the cytoplasmic membrane that allows for the passage of ions and other molecules into the cell. The molecular weight of Tetanolysin is approximately 55,000 daltons. [http://www.listlabs.com/Literature/199.htm]

References

*Alouf, J. (1997) pp 7-10 in "Guidebook to Protein Toxins and Their Use in Cell Biology", Ed. Rappuoli, R. and Montecucco, C. (Oxford University Press).
*Ahnert-Hilger, G., Pahner, I., and Höltje, M. (1999) "Pore-forming Toxins as Cell Biological and Pharmacological Tools." In press.
*Conti, A., Brando, C., DeBell, K.E., Alava, M.A., Hoffman, T., Bonvini, E. (1993) "J. Biol. Chem." 268, 783-791.
*Raya, S.A., Trembovler, V., Shohami, E. and Lazarovici, P. (1993) "Nat. Toxins" 1, 263-70.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • tetanolysin — (tet ah nol ī sin) A hemolysin that aids in tissue destruction and is produced by Clostridium tetani …   Dictionary of microbiology

  • tetanolysin — Thiol activated haemolysin released by the bacterium Clostridium tetani …   Dictionary of molecular biology

  • tetanolysin — A hemolytic principle, elaborated by Clostridium tetani, which seems to have no role in the etiology of tetanus. * * * tet·a·no·ly·sin .tet ə näl ə sən, .tet ən ō līs ən n a hemolytic toxin produced by the tetanus bacillus (Clostridium tetani) *… …   Medical dictionary

  • tetanolysin — tet·a·no·lysin …   English syllables

  • tetanolysin — n. a toxin produced by tetanus bacilli in an infected wound, causing the local destruction of tissues …   The new mediacal dictionary

  • tetanolysin — |tetənō+ noun Etymology: International Scientific Vocabulary tetan + lysin : a hematolytic toxin produced by the tetanus bacillus …   Useful english dictionary

  • Clostridium tetani — with characteristic tennis racket appearance. Scientific classification Kingdom …   Wikipedia

  • Starrkrampf — Klassifikation nach ICD 10 A33 Tetanus neonatorum A34 Tetanus während der Schwangerschaft, der Geburt und des Wochenbettes A35 …   Deutsch Wikipedia

  • Tetanus — Klassifikation nach ICD 10 A33 Tetanus neonatorum A34 Tetanus während der Schwangerschaft, der Geburt und des Wochenbettes …   Deutsch Wikipedia

  • Wundstarrkrampf — Klassifikation nach ICD 10 A33 Tetanus neonatorum A34 Tetanus während der Schwangerschaft, der Geburt und des Wochenbettes A35 …   Deutsch Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.