BSC is a three-letter abbreviation that may refer to:

Science and technology
* Bachelor of Science, an academic degree
* Base Station Controller, part of a mobile phone network; see: Base Station Subsystem
* Basic Spacing between Centers, integrated circuit package dimension
* Binary symmetric channel, in coding theory
* Binary Synchronous Communications, a data link protocol
* Biological species concept, a concept in biological classification.
* Broadcom Serial Control, camera interface
* Bristol Stool Chart, see: Bristol Stool Scale

Places and institutions
* Barcelona Sporting Club, an Ecuadorian football club based in Guayaquil
* Barcelona Supercomputing Center
* Bear Stearns, an investment bank whose NYSE ticker symbol was BSC until JPMorgan Chase bought Bear Stearns out and subsequently delisted the stock
* Birmingham-Southern College
* Bismarck State College
* Bluefield State College, Bluefield, WV, U.S.
* Brentwood Secondary College, Melbourne, Australia
* Bridgewater State College, Massachusetts, U.S.
* British Security Coordination, a covert organization in the U.S. during World War II
* British Sugar Corporation
* British Society of Cinematographers
* Broadcasting Standards Commission
* Broglio Space Centre, the Italian spaceport; see: San Marco platform
* Bryant & Stratton College, headquartered in Buffalo, New York, U.S.
* Buffalo State College, a unit of the State University of New York

* Balanced scorecard, a method for measuring a company's activities
* "The Beacon Street Collection", an album by No Doubt
* Black Stone Cherry, a rock band
* Blood Stain Child, a Japanese band
* The Baby-sitters Club, a series of books
* Bi-State Conference, a collegiate sports conference
* Bronze Swimming Certificate, an award swimmers can get for completing certain tasks

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