P14arf


P14arf

protein
Name=cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
caption=


width=
HGNCid=1787
Symbol=CDKN2A
AltSymbols=CDKN2, MLM
EntrezGene=1029
OMIM=600160
RefSeq=NM_000077
UniProt=P42771
PDB=
ECnumber=
Chromosome=9
Arm=p
Band=21
LocusSupplementaryData=

p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in MDM2 and therefore loss of p53 function and cell cycle control.

External links

*


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • p14arf — This article is about a tumor supressor gene. For ARF small GTP binding protein, see ADP ribosylation factor. cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Identifiers Symbol CDKN2A Alt. symbols CDKN2, MLM Entrez …   Wikipedia

  • p16 (gene) — Cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) PDB rendering based on 1a5e …   Wikipedia

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP …   Wikipedia

  • ARF tumor suppressor — The ARF tumor suppressor is a protein that is transcribed from an alternate reading frame of the INK4a/ARF locus (CDKN2A).[1] ARF is induced in response to sustained mitogenic stimulation, such as aberrant growth signaling from MYC and Ras… …   Wikipedia

  • Mdm2 — Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) Estructura tridimensional de la proteína Mdm2. HUGO 6973 …   Wikipedia Español

  • P16 — Inhibidor 2A de quinasa dependiente de ciclina Estructura tridimensional de la proteína p16. HUGO …   Wikipedia Español

  • P53 — (also known as protein 53 or tumor protein 53), is a transcription factor encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in… …   Wikipedia

  • P16 (gene) — Cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), also known as CDKN2A, is a human gene.This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding… …   Wikipedia

  • Cell cycle — For the separation of chromosomes that occurs as part of the cell cycle, see mitosis. For the Academic journal, see Cell Cycle. Each turn of the cell cycle divides the chromosomes in a cell nucleus. The cell cycle, or cell division cycle, is the… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.