Name=cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
p14ARF is an alternate reading frame (ARF) product of the
CDKN2Alocus. Both p16INK4aand p14ARF are involved in cell cycleregulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21activation, which then binds and inactivates certain cyclin- CDKcomplexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in MDM2and therefore loss of p53function and cell cycle control.
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p14arf — This article is about a tumor supressor gene. For ARF small GTP binding protein, see ADP ribosylation factor. cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Identifiers Symbol CDKN2A Alt. symbols CDKN2, MLM Entrez … Wikipedia
p16 (gene) — Cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) PDB rendering based on 1a5e … Wikipedia
Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2.  … Wikipedia
p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP … Wikipedia
ARF tumor suppressor — The ARF tumor suppressor is a protein that is transcribed from an alternate reading frame of the INK4a/ARF locus (CDKN2A). ARF is induced in response to sustained mitogenic stimulation, such as aberrant growth signaling from MYC and Ras… … Wikipedia
Mdm2 — Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) Estructura tridimensional de la proteína Mdm2. HUGO 6973 … Wikipedia Español
P16 — Inhibidor 2A de quinasa dependiente de ciclina Estructura tridimensional de la proteína p16. HUGO … Wikipedia Español
P53 — (also known as protein 53 or tumor protein 53), is a transcription factor encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in… … Wikipedia
P16 (gene) — Cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), also known as CDKN2A, is a human gene.This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding… … Wikipedia
Cell cycle — For the separation of chromosomes that occurs as part of the cell cycle, see mitosis. For the Academic journal, see Cell Cycle. Each turn of the cell cycle divides the chromosomes in a cell nucleus. The cell cycle, or cell division cycle, is the… … Wikipedia