Butenafine

Butenafine

Systematic (IUPAC) name
[(4-tert-butylphenyl)methyl](methyl)(naphthalen-1-ylmethyl)amine
Clinical data
Trade names	Mentax
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	?
Routes	topical
Pharmacokinetic data
Metabolism	Hepatic
Half-life	35-100 hours
Identifiers
CAS number	101828-21-1
ATC code	D01AE23
PubChem	CID 2484
DrugBank	APRD00833
ChemSpider	2390 Y
UNII	91Y494NL0X Y
KEGG	D07596 Y
ChEBI	CHEBI:3238 Y
ChEMBL	CHEMBL990 Y
Chemical data
Formula	C23H27N
Mol. mass	317.47 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3 Y Key:ABJKWBDEJIDSJZ-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Butenafine hydrochloride is a synthetic benzylamine antifungal, marketed under the trade names Mentax, Butop (India) and is the active ingredient in Schering-Plough's Lotrimin Ultra. It is structurally related to synthetic allylamine antifungals such as terbinafine.

Pharmacology

Butenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water.

Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out.

Indications

Butenafine is indicated for the topical treatment of tinea (pityriasis) versicolor due to M. furfur, as well as athlete’s foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans. It has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, clotrimazole, and tolnaftate.

It also displays superior activity against Candida albicans when compared against terbinafine and naftifine. Butenafine demonstrates low minimum inhibitory concentrations against cryptococcus and aspergillus.

Butenafine is typically available as a 1% topical cream.

Typical usage

For 1% cream

• for adults and children 12 years and older
• wash the affected skin with soap and water and dry completely before applying
• apply once a day to affected skin for 2 weeks or as directed by a doctor
• wash hands after each use
• children under 12 years: ask a doctor

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This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Antifungals Naphthalenes Amines Antiinfective agent stubs Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Andrea Occhipinti Dillwynia tenuifolia Look at other dictionaries: butenafine — noun A synthetic benzylamine antifungal drug …   Wiktionary butenafine hydrochloride — bu·ten·a·fine hy·dro·chlo·ride (bu tenґə fēn) an antifungal that blocks the synthesis of ergosterol, a component of cell membranes in fungi; used topically in the treatment of tinea pedis, tinea corporis, and tinea cruris …   Medical dictionary Salicylic acid — Salicylic acid …   Wikipedia Pentamidine — Systematic (IUPAC) name 4,4 [pentane 1,5 diylbis(ox …   Wikipedia Ringworm — Infobox Disease Name = Ringworm Caption = Ringworm on the arm DiseasesDB = 17492 ICD10 = ICD10|B|35|4|b|35 ICD9 = ICD9|110.9 ICDO = OMIM = MedlinePlus = eMedicineSubj = emerg eMedicineTopic = 592 MeshID = D014005 Ringworm (also called serpigo) is …   Wikipedia Antifungal drug — An antifungal drug is medication used to treat fungal infections such as athlete s foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor s… …   Wikipedia Itraconazole — Systematic (IUPAC) name (2R,4S) rel 1 (butan 2 yl) 4 {4 [4 (4 {[(2R,4S) 2 (2,4 dichlorophenyl) 2 (1H 1,2,4 triazol 1 ylmethyl) 1,3 dioxolan 4 yl]methoxy}phenyl)piperazin 1 yl]phenyl} 4,5 dihydro 1H 1,2,4 …   Wikipedia Tea tree oil — (Melaleuca Oil) Tea tree oil, or melaleuca oil, is a pale yellow colour to nearly clear essential oil with a fresh camphoraceous odor.[1] It is taken from the leaves of the …   Wikipedia Nystatin — Systematic (IUPAC) name (1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E, 25E,27E,29E,31E,33R,35S,36R,37S) 33 [(3 amino 3 …   Wikipedia Amphotericin B — Systematic (IUPAC) name (1R,3S,5R,6R,9 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”