D-amino acid oxidase

D-amino-acid oxidase
Identifiers
EC number	1.4.3.3
CAS number	9000-88-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

D-amino-acid oxidase
Identifiers
Symbol	DAO (DAAO)
Entrez	1610
HUGO	2671
OMIM	124050
RefSeq	NM_001917
UniProt	P14920
Other data
EC number	1.4.3.3
Locus	Chr. 12 q24

D-amino acid oxidase (DAAO; also DAO, OXDA, DAMOX) is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human.^[1] It is not present in bacteria or in plants. Its function is to oxidize D-amino acids to the corresponding imino acids, producing ammonia and hydrogen peroxide.

This enzyme belongs to the FAD dependent oxidoreductase family, and acts on the CH-NH2 group of D-amino acid donors with oxygen as acceptor. The enzyme is most active toward neutral D-amino acids, and not active toward acidic D-amino acids.

Recently, mammalian D-amino acid oxidase has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission. In a postmortem study, the activity of DAAO was found to be two-fold higher in schizophrenia.^[2]

DAAO is a candidate susceptibility gene^[3] and together with G72 may play a role in the glutamatergic mechanisms of schizophrenia.^[4]

DAAO is used as a biocatalyst in several biotechnological application, such as the oxidation of cephalosporin C, the deracemition of racemic D-amino acid solutions and as the biolocical component in several biosensors.

See also

• D-amino acid oxidase activator
• D-amino acid dehydrogenase
• D-aspartate oxidase

External links

• MeSH D-Amino-Acid+Oxidase
• http://www.calzyme.com/commerce/catalog/spcategory.jsp?category_id=1043

References

1. ^ Pollegioni L, Piubelli L, Sacchi S, Pilone MS, Molla G (June 2007). "Physiological functions of D-amino acid oxidases: from yeast to humans". Cell. Mol. Life Sci. 64 (11): 1373–94. doi:10.1007/s00018-007-6558-4. PMID 17396222. 
2. ^ Madeira C, Freitas ME, Vargas-Lopes C, Wolosker H, Panizzutti R (April 2008). "Increased brain d-amino acid oxidase (DAAO) activity in schizophrenia". Schizophr. Res. 101 (1–3): 76–83. doi:10.1016/j.schres.2008.02.002. PMID 18378121. http://linkinghub.elsevier.com/retrieve/pii/S0920-9964(08)00097-2. 
3. ^ Gene Overview of All Published Schizophrenia-Association Studies for DAAO - SZGene database.
4. ^ Boks MP, Rietkerk T, van de Beek MH, Sommer IE, de Koning TJ, Kahn RS (September 2007). "Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia". Eur Neuropsychopharmacol 17 (9): 567–72. doi:10.1016/j.euroneuro.2006.12.003. PMID 17250995. http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(06)00260-4. 

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.v · Categories: Genes on chromosome 12 Oxidoreductase stubs EC 1.4.3 Flavin enzymes Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат HMS Diomede (D92) South West of England Regional Development Agency Look at other dictionaries: L-amino-acid oxidase — In enzymology, a L amino acid oxidase (EC number|1.4.3.2) is an enzyme that catalyzes the chemical reaction:an L amino acid + H2O + O2 ightleftharpoons a 2 oxo acid + NH3 + H2O2The 3 substrates of this enzyme are L amino acid, H2O, and O2,… …   Wikipedia N-methyl-L-amino-acid oxidase — Identifiers EC number 1.5.3.2 CAS number 9029 23 6 …   Wikipedia D-amino acid oxidase activator — Identifiers Symbol DAOA Alt. symbols G72, LG72, SG72 Entrez 267012 …   Wikipedia L-amino-acid oxidase — L ami·no ac·id ox·i·dase (ə meґno asґid okґsĭ dās) [EC 1.4.3.2] an enzyme of the oxidoreductase class that catalyzes the oxidative deamination of L amino acids to form 2 keto acids, producing hydrogen peroxide as a byproduct. The… …   Medical dictionary D-amino-acid oxidase — D ami·no ac·id ox·i·dase (ə meґno asґid okґsĭ dās) [EC 1.4.3.3] an enzyme of the oxidoreductase class that catalyzes the oxidative deamination of D amino acids to form 2 keto acids, producing hydrogen peroxide as a byproduct. The… …   Medical dictionary Amino acid oxidoreductases — are oxidoreductases, a type of enzyme, that act upon amino acids.They constitute the majority of enzymes classified under EC number 1.4, with most of the remainder being monoamine oxidases.Examples include: * Glutamate dehydrogenase * Nitric… …   Wikipedia Amino acid — This article is about the class of chemicals. For the structures and properties of the standard proteinogenic amino acids, see Proteinogenic amino acid. The generic structure of an alpha amino acid in its unionized form …   Wikipedia D-amino acid dehydrogenase — (EC 1.4.99.1) is a bacterial enzyme that catalyses the oxidation of D amino acids into their corresponding oxoacids. It contains both flavin and nonheme iron as cofactors.[1] The enzyme has a very broad specificity and can act on most D amino… …   Wikipedia Aromatic L-amino acid decarboxylase — Ribbon diagram of a domestic pig DOPA decarboxylase dimer.[1] …   Wikipedia Aromatic L-amino acid decarboxylase inhibitor — An aromatic L amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”