Enhanceosome


Enhanceosome

The enhanceosome is a protein complex that binds to the "enhancer" region of a gene, found upstream or downstream, of the promoter, or within a gene. It accelerates the gene's transcription. The binding and assembly of the activating proteins, some of which may be transcription factors, is cooperative due to energetically favorable protein-protein interactions formed in the complex.

The best known example of the enhanceosome acts on the human interferon-beta gene, which is upregulated in cells that are infected by viruses. Three activator proteins - NF-kB, an interferon activator protein such as IRF6, and the Jun/ATF complex - cooperatively bind to the upstream enhancer region upon viral infection. The interaction is mediated by a fourth protein HMG-I, which assists in stabilizing the complex by promoting inter-protein interactions. The assembled enhanceosome recruits transcriptional machinery such as RNA polymerase to the promoter region to initiate gene expression.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • enhanceosome — noun A protein complex that binds to the region of a gene …   Wiktionary

  • Developmental biology — Developmental genetics redirects here. For the journal formerly known as Developmental Genetics, see Genesis (journal). For the journal, see Developmental Biology (journal). Views of a Fetus in the Womb , Leonardo da Vinci, ca. 1510 1512. The… …   Wikipedia

  • Evolutionary developmental biology — (evolution of development or informally, evo devo) is a field of biology that compares the developmental processes of different animals and plants in an attempt to determine the ancestral relationship between organisms and how developmental… …   Wikipedia

  • Glucocorticoid receptor — Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Crystallographic structures of the glucocorticoid receptor DNA binding domain (DBD, left, PDB 1R4O bound to DNA) and ligand bindin …   Wikipedia

  • NFYB — Nuclear transcription factor Y, beta PDB rendering based on 1n1j …   Wikipedia

  • IRF5 — Interferon regulatory factor 5, also known as IRF5, is a human gene.cite web | title = Entrez Gene: IRF5 interferon regulatory factor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3663| accessdate = ]… …   Wikipedia

  • UXT — Ubiquitously expressed transcript, also known as UXT, is a human gene.cite web | title = Entrez Gene: UXT ubiquitously expressed transcript| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=8409| accessdate …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.