- Drug delivery
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release is from: diffusion, degradation, swelling, and affinity-based mechanisms. Most common routes of administration include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.
Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.
- Targeted drug delivery
- Thin film drug delivery
- Self-microemulsifying drug delivery system
- Acoustic targeted drug delivery
- Neural drug delivery systems
- Drug carrier
- M. N. V. Ravi Kumar (2008), Handbook of Particulate Drug Delivery (2-Volume Set), American Scientific Publishers. ISBN 1-58883-123-X
- ^ "Definition". http://www.buildingbiotechnology.com/glossary2.php. Retrieved 2008-05-01.
- ^ "Definition". http://www.biostrategy.gc.ca/english/View.asp?mid=413&x=696. Retrieved 2008-05-01.
- ^ Wang, NX.; von Recum, HA. (2011). "Affinity-Based Drug Delivery". Macromol Biosci 11: 321–332. doi:10.1002/mabi.201000206.
- ^ "Definition". http://www.pharmacircle.com/dynamic/charts.php?kind=48. Retrieved 2008-05-27.
- ^ "Definition". http://www.pharmacircle.com/index.php?page=free/drug_delivery.php&expand=2. Retrieved 2008-05-27. [dead link]
- ^ Bertrand N, Leroux JC. (2011). "The journey of a drug carrier in the body: an anatomo-physiological perspective". Journal of Controlled Release. doi:10.1016/j.jconrel.2011.09.098. http://www.sciencedirect.com/science/article/pii/S0168365911009527.
- Article in Chemical and Engineering News
- Drug Delivery Reports
- Nano-Tera.ch-Drug Delivery News
- Home of Langer Lab, one of the pioneers in Drug Delivery Systems
Wikimedia Foundation. 2010.
Look at other dictionaries:
drug delivery — Method by which a drug is delivered to its site of action. For traditional drugs this is another name for formulation. However, biotechnology has allowed the development of a range of new therapeutic agent delivery systems, such as liposomes and… … Glossary of Biotechnology
Drug Delivery (journal) — Drug Delivery > Abbreviated title (ISO) … Wikipedia
Thin film drug delivery — Drug film redirects here. For movies featuring substance abuse, see List of drug films. Thin film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the… … Wikipedia
Targeted drug delivery — Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. The goal of a targeted … Wikipedia
Neural drug delivery systems — Neural drug delivery is the next step beyond the basic addition of growth factors to nerve guidance conduits. Drug delivery systems allow the rate of growth factor release to be regulated over time, which is critical for creating an environment… … Wikipedia
Acoustic targeted drug delivery — (ATDD) is a method that uses ultrasound energy to enhance the transport of molecules into and/or across specific tissues. Generally this class of ultrasound energy falls under the class of therapeutic ultrasound, and ranges in ultrasonic… … Wikipedia
Advanced Drug Delivery Reviews — Titre abrégé Adv. Drug Deliv. Rev. Discipline Pharmacologie Langue Anglais … Wikipédia en Français
targeted drug delivery — A method of delivering the activated form of a drug molecule to the site in the body where it is needed, rather than allowing it reach the target by uncontrolled diffusion … Glossary of Biotechnology
Drug Targeting — oder Targeted Drug Delivery ist die zielgerichtete und selektive Anreicherung oder Freisetzung eines Arzneistoffs am gewünschten Wirkort nach einer systemischen Verabreichung eines Medikaments. Auf diese Weise sollen die Effektivität der Wirkung… … Deutsch Wikipedia
Drug-eluting stent — Intervention An example of a drug eluting stent. This is the TAXUS Express2 Paclitaxel Eluting Coronary Stent System, which releases paclitaxel. ICD 9 CM … Wikipedia