Pribnow box


Pribnow box

The Pribnow box (also known as the Pribnow-Schaller box) is the sequence "TATAAT" of six nucleotides (thymine-adenine-thymine-etc.) that is an essential part of a promoter site on DNA for transcription to occur in bacteria. [David Pribnow (1975). Nucleotide sequence of an RNA Polymerase Binding Site at an Early T7 Promoter. Proc. Natl. Acad. Sci. USA 72:784-788.] [Heinz Schaller, Christopher Gray, and Karin Herrman (1975). Nucleotide Sequence of an RNA Polymerase Binding Site from the DNA of Bacteriophage fd. Proc. Natl. Acad. Sci. USA 72:737-741.] It is an idealized or consensus sequence - that is, it shows the most frequently occurring base at each position in a large number of promoters analyzed; individual promoters often vary from the consensus at one or more positions. It is also commonly called the -10 sequence, because it is centered roughly 10 base pairs upstream from the site of initiation of transcription.

The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes(+archaea): it is recognized and bound by a subunit of RNA polymerase during initiation of transcription. This region of the DNA is also the first place where base pairs separate to allow access to one strand as the template for transcription. The AT-richness is important to allow this separation, since adenine and thymine pair together with only two hydrogen bonds (as opposed to three as with guanine and cytosine), they are easier to break apart.

Probability of occurrence of each nucleotide [Calvin B. Harley and Robert P. Reynolds (1987). Analysis of "E. coli" promoter sequences. Nucleic Acids Res. 15(5):2343-61.]

The Pribnow box or Pribnow-Schaller box is named after David Pribnow and Heinz Schaller.

ee also

* TATA box

References


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Look at other dictionaries:

  • Pribnow box — Pribnow box. См. бокс Прибнова. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Pribnow-Box — Die Pribnow Box, auch Pribnow Schaller Box, ist ein 1975 von David Pribnow und Heinz Schaller gefundenes Promotor Element zur Genregulation der Transkription, also der Umschreibung eines Gens von DNA in RNA, bei Bakterien und… …   Deutsch Wikipedia

  • Pribnow box — Consensus sequence near the mRNA start point of prokaryotic genes. See: TATA box …   Glossary of Biotechnology

  • Pribnow box — A special base sequence in the promoter that is recognized by the RNA polymerase and is the site of initial polymerase binding …   Dictionary of microbiology

  • Pribnow box — See promoter …   Dictionary of molecular biology

  • box — Container; receptacle. [L.L. buxis, fr. G. puxis, b. tree] black b. 1. (Jargon) descriptive of a method of reasoning or studying a problem, in which the methods and procedures, as such, are not described, explained, or perhaps even understood:… …   Medical dictionary

  • Pribnow — David, 20th century U.S. molecular biologist. See P. box …   Medical dictionary

  • TATA Box — Die TATA Box, auch Goldberg Hogness Box, ist eine 1978 von Michael Goldberg und David Hogness gefundene DNA Sequenz in der Promotorregion eines Gens, zur Genregulation der Transkription bei Eukaryoten.[1] Auch in Archaeen findet sich die TATA Box …   Deutsch Wikipedia

  • TATA-Box — Die TATA Box, auch Goldberg Hogness Box, ist eine 1978 von Michael Goldberg und David S. Hogness gefundene DNA Sequenz in der Promotorregion eines Gens, zur Genregulation der Transkription bei Eukaryoten.[1] Auch in Archaeen findet sich die TATA… …   Deutsch Wikipedia

  • TATA box — The TATA box (also called Goldberg Hogness box) [Lifton RP, Goldberg ML, Karp RW, Hogness DS. (1978). The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications. Cold Spring Harb Symp Quant Biol. 42 …   Wikipedia


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