- Elongation factor
Elongation factors are a set of proteins that facilitate the events of translational elongation, the steps in protein synthesis from the formation of the first
peptide bondto the formation of the last one.
Elongation is the most rapid step in translation:
prokaryotesit proceeds at a rate of 15 to 20 amino acidsadded per second (about 60 nucleotides per second)
eukaryotesthe rate is about two amino acids per second.
Elongation factors play a role in orchestrating the events of this process, and in ensuring the 99.99% accuracy of translation at this speed.
Prokaryotic elongation factors
Eukaryotic elongation factors Corynebacterium diptheriaealters protein function in the host by inactivating elongation factor (EF-2). This causes pharyngitis and 'pseudomembrane' in the throat.
*Alberts, B. et al. (2002). "Molecular Biology of the Cell", 4th ed. New York: Garland Science. ISBN 0-8153-3218-1
*Berg, J. M. et al. (2002). "Biochemistry", 5th ed. New York: W.H. Freeman and Company. ISBN 0-7167-3051-0
*Singh, B. D. (2002). "Fundamentals of Genetics", New Delhi, India: Kalyani Publishers. ISBN 81-7663-109-4
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elongation factor — elongation factor. См. фактор элонгации [EF G у прокариот]. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
elongation factor — Peptidyl transferase components of ribosomes that catalyse formation of the acyl bond between the incoming amino acid residue and the peptide chain. There are three classes of elongation factor: EF1 a (EF Tu in prokaryotes) binds GTP and… … Dictionary of molecular biology
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factor — 1. One of the contributing causes in any action. 2. One of the components that by multiplication makes up a number or expression. 3. SYN: gene. 4. A vitamin or other essential element. 5. An event, characteristic, or other definable entity that … Medical dictionary
Prokaryotic elongation factors — In prokaryotes, three elongation factors are required for translation: EF Tu, EF Ts, and EF G. EF Tu The prokaryotic factor EF Tu (elongation factor thermo unstable) mediates the entry of the aminoacyl tRNA into a free site of the ribosome. EF Tu … Wikipedia
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