- Hormone receptor
hormone receptoris a receptor proteinon the surface of a cell or in its interior that binds to a specific hormone. The hormone causes many changes to take place in the cell.
Binding of hormones to hormone receptors often trigger the start of a biophysical signal that can lead to further
signal transduction pathways, or trigger the activation or inhibition of genes. [ [http://www.bio-balance.com/Graphics.htm http://www.bio-balance.com/ ] ]
Types of Hormone Receptors
Peptide hormonereceptors are often transmembrane proteins. They are also called G-protein-coupled receptors, sensory receptors or ionotropic receptors. These receptors generally function via intracellular second messengers, including cyclic AMP(cAMP), inositol 1,4,5-trisphosphate (IP3) and the calcium (Ca2+)- calmodulinsystem.
Steroid hormone receptors and related receptors are generally soluble proteins that function through gene activation. Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The receptors themselves are zinc-fingerproteins. [ [http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SteroidREs.html Steroid Hormone Receptors and their Response Elements] ] These receptors include those for glucocorticoids, estrogens, androgens, thyroid hormone(T3), calcitriol(the active form of vitamin D), and the retinoids ( vitamin A).
Wikimedia Foundation. 2010.
См. также в других словарях:
hormone receptor — A protein on the surface of a cell that binds to a specific hormone. The hormone causes many changes to take place in the cell … English dictionary of cancer terms
Hormone receptor positive tumor — A hormone receptor positive tumor is a tumor which consists of cells that express receptors for certain hormones. The term most commonly refers to estrogen receptor positive tumors (i.e. tumors that contain estrogen receptor positive cells), but… … Wikipedia
hormone receptor test — A test to measure the amount of certain proteins, called hormone receptors, in cancer tissue. Hormones can attach to these proteins. A high level of hormone receptors may mean that hormones help the cancer grow … English dictionary of cancer terms
Thyroid hormone receptor beta — Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) PDB rendering based on 1bsx … Wikipedia
Melanin-concentrating hormone receptor 1 — Identifiers Symbols MCHR1; GPR24; MCH1R; MGC32129; SLC1 External IDs … Wikipedia
Thyroid hormone receptor alpha — Thyroid hormone receptor, alpha PDB rendering based on 1nav … Wikipedia
Growth hormone releasing hormone receptor — The growth hormone releasing hormone receptor (GHRHR) is a G protein coupled receptor which binds growth hormone releasing hormone.cite journal | author = Gaylinn BD | title = Growth hormone releasing hormone receptor | journal = Recept. Channels … Wikipedia
Corticotropin releasing hormone receptor 1 — Rendering based on PDB 3EHS … Wikipedia
Steroid hormone receptor — Steroid hormone receptors are intracellular receptors (typically cytoplasmic) that perform signal transduction for steroid hormones. Steroid hormone receptors are part of the nuclear receptor family that include a group of homologous structured… … Wikipedia
Parathyroid hormone receptor 1 — is a parathyroid hormone receptor It is encoded by the gene PTHR1 . It is a receptor for parathyroid hormone (PTH) and for parathyroid hormone like hormone (PTHLH).FunctionIt is the classical PTH receptor, is expressed in high levels in bone and… … Wikipedia