Bioassay is a shorthand commonly used term for biological assay and is a type of scientific
Bioassays are typically conducted to measure the effects of a substance on a living . Bioassays may be or . Qualitative bioassays are used for assessing the physical effects of a substance that may not be quantified, such as abnormal development or
deformity. An example of a qualitative bioassay includes Arnold Adolph Berthold's famous experiment on castrated chickens. This analysis found that by removing the testes of a chicken, it would not develop into a rooster because the endocrine signals necessary for this process weren't available. Quantitative bioassays involve estimation of the concentration or potency of a substance by measurement of the biological response that it produces. Quantitative bioassays are typically analyzed using the methods of biostatistics.
The use of bioassays include:
# measurement of the pharmacological activity of new or chemically undefined substances
# investigation of the function of
# determination of the side-effect profile, including the degree of
# measurement of the concentration of known substances (alternatives to the use of whole animals have made this use obsolete)
#Assessing the amount of pollutants being released by a particular source, such as
wastewateror urban runoff.
Bioassays are essential in the development of new
drugs, and monitoring pollutants in the environment. Environmental bioassays are generally a broad-range survey of toxicity, and a toxicity identification evaluation is conducted to determine what the relevant toxicants are. Although bioassays are beneficial in determining the biological activity within an organism, they can often be time-consuming, laborious, and organism-specific factors may result in data that isn't applicable to others in that species. For these reasons, other biological techniques are often employed, including radioimmunoassays.
* [http://www.toxicitylab.com/content/services/toxicity_testing_faq.php#Bioassay What is a bioassay (ToxicityLab.com)?]
* [http://www.nj.gov/dep/oqa/powerpoint/DEPBasicsCourse.ppt Whole Effluent Toxicity Basics (PowerPoint file)]
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bioassay — ioassay n. appraisal of the biological activity of a substance by testing its effect on an organism. [WordNet 1.5] … The Collaborative International Dictionary of English
bioassay — ioassay v. 1 to subject to a bio assay. Syn: bio assay. [WordNet 1.5] … The Collaborative International Dictionary of English
bioassay — bioassay. См. биопроба. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
bioassay — ☆ bioassay [bī΄ō as′ā ] n. [ BIO + ASSAY] a technique for determining the power of a drug or other substance by measuring its effects on a test specimen against those of a standard substance … English World dictionary
bioassay — noun Date: 1912 determination of the relative strength of a substance (as a drug) by comparing its effect on a test organism with that of a standard preparation • bioassay transitive verb … New Collegiate Dictionary
bioassay — n. /buy oh euh say , as ay/; v. /buy oh euh say /, n., v., bioassayed, bioassaying. n. 1. determination of the biological activity or potency of a substance, as a vitamin or hormone, by testing its effect on the growth of an organism. v.t. 2. to… … Universalium
bioassay — Determination of the potency or concentration of a compound by its effect upon animals, isolated tissues, or microorganisms, as compared with an analysis of its chemical or physical properties. * * * bio·as·say as .ā, a sā n determination of the… … Medical dictionary
bioassay — n. estimation of the activity or potency of a drug or other substance by comparing its effects on living organisms with effects of a preparation of known strength. Bioassay is used to determine the strength of preparations of hormones or other… … The new mediacal dictionary
bioassay — bi•o•as•say n. [[t]ˌbaɪ oʊ əˈseɪ, ˈæs eɪ[/t]] v. [[t]ˌbaɪ oʊ əˈseɪ[/t]] n. 1) lab determination of the biological activity or potency of a substance, as a vitamin or hormone, by testing its effect on the growth of an organism 2) lab to subject to … From formal English to slang
bioassay — biologinis tyrimas statusas T sritis Standartizacija ir metrologija apibrėžtis Kokybiškas arba kiekybiškas biologinio įvairių priemaišų poveikio nustatymas pagal tam tikro biologinio aktyvumo pokytį. atitikmenys: angl. bioassay vok. biologischer… … Penkiakalbis aiškinamasis metrologijos terminų žodynas