Androstenediol

Androstenediol

Androstenediol is a term used to refer to two different steroids with molecular weights of 290.44. They are 4-androstenediol (4-androstene-3beta,17beta-diol) and 5-androstenediol (5-androstene-3beta,17beta-diol).

4-Androstenediol is closer to testosterone structurally, and has androgenic effects.

5-Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, dehydroepiandrosterone (DHEA). 5-Androstenediol is less androgenic than 4-androstenediol, and stimulates the immune system. When administered to rats in vivo, 5-androstenediol has approximately 1/70 the androgenicity of DHEA, 1/185 the androgenicity of androstenedione, and 1/475 the androgenicity of testosterone (Coffey, 1988). Because it induces production of white blood cells and platelets, 5-androstenediol is being developed as a radiation countermeasure by the Armed Forces Radiobiology Research Institute. Until 2007, it was being developed as a radiation countermeasure by Hollis-Eden Pharmaceuticals as Neumune (HE2100).

Androstenediol is on the list of substances banned by the Major League Baseball drug policy.

ee also

*Androstenedione

References

*
*
* Coffey, DS (1988) "Androgen action and the sex accessory tissues". In E Knobil, J Neill (eds), The Physiology of Reproduction. Raven Press, New York, pp 1081-1119.
*
*
*
*
*
*
*


Wikimedia Foundation. 2010.

См. также в других словарях:

  • androstenediol — 5 Androsten 3β,17β diol; a steroid metabolite differing from androstanediol by possessing a double bond between C 5 and C 6. * * * an·dro·stene·di·ol (an″dro stēn diґol) ( stēnґde ol) a testosterone metabolite, C19H30O2, occurring …   Medical dictionary

  • 5-Androstenediol — Systematic (IUPAC) name (3S,8R,9S …   Wikipedia

  • 5-Androstenediol — Nombre (IUPAC) sistemático …   Wikipedia Español

  • 4-Androstenediol — Nombre (IUPAC) sistemático …   Wikipedia Español

  • Neumune — Androstenediol Général No CAS …   Wikipédia en Français

  • Testosterone — For the film, see Testosterone (film). Testosterone Systematic (IUPAC) name …   Wikipedia

  • Dihydrotestosterone — Systematic (IUPAC) name (5S,8 …   Wikipedia

  • Hormone replacement therapy (female-to-male) — Hormone replacement therapy (HRT) for transgender and transsexual people replaces the hormones naturally occurring in their bodies with those of the other sex. However, not all cases of hormone replacement therapy are used by transgendered people …   Wikipedia

  • Dehydroepiandrosterone — Systematic (IUPAC) name (3S,8R,9S,10 …   Wikipedia

  • Prohormone — A prohormone is a substance that is a precursor to a hormone, usually having minimal hormonal effect by itself. The term has been used in medical science since the middle of the 20th century. Examples of natural, human prohormones include… …   Wikipedia


Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»