Androstenediol is a term used to refer to two different
steroids with molecular weights of 290.44. They are 4-androstenediol(4-androstene-3beta,17beta-diol) and 5-androstenediol(5-androstene-3beta,17beta-diol).
4-Androstenediol is closer to
testosteronestructurally, and has androgenic effects.
5-Androstenediol is a direct
metaboliteof the most abundant steroidproduced by the human adrenal cortex, dehydroepiandrosterone(DHEA). 5-Androstenediol is less androgenic than 4-androstenediol, and stimulates the immune system. When administered to rats in vivo, 5-androstenediol has approximately 1/70 the androgenicity of DHEA, 1/185 the androgenicity of androstenedione, and 1/475 the androgenicity of testosterone(Coffey, 1988). Because it induces production of white blood cells and platelets, 5-androstenediol is being developed as a radiationcountermeasure by the Armed Forces Radiobiology Research Institute. Until 2007, it was being developed as a radiationcountermeasure by Hollis-Eden Pharmaceuticals as Neumune(HE2100).
Androstenediol is on the list of substances banned by the
Major League Baseball drug policy.
* Coffey, DS (1988) "Androgen action and the sex accessory tissues". In E Knobil, J Neill (eds), The Physiology of Reproduction. Raven Press, New York, pp 1081-1119.
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См. также в других словарях:
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