Bcl-2-associated X protein


Bcl-2-associated X protein

The Bcl-2–associated X protein, or BAX, gene was the first identified pro-apoptotic member of the Bcl-2 protein family. [

] Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

BAX is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. In healthy mammalian cells, the majority of BAX is found in the cytosol, but upon initiation of apoptotic signaling, BAX undergoes a conformation shift, and inserts into organelle membranes, primarily the outer mitochondrial membrane. [

] BAX is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel, VDAC. Alternatively, growing evidence suggest that activated Bax and/or Bak form an oligomeric pore, MAC in the outer membrane. This results in the the release of cytochrome c and other pro-apoptotic factors from the mitochondria, often referred to as mitochondrial outer membrane permeabilization, leading to activation of caspases. This defines a direct role for Bax in mitochondrial outer membrane permeabilization, a role common to the Bcl-2 proteins containing the BH1, BH2 and BH3 domains.

The expression of "BAX" is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis. The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including "BAX". However, p53 also has a transcription-independent role in apoptosis. In particular, p53 interacts with BAX, promoting its activation as well as its insertion into the mitochondrial membrane.

ee also

* Apoptosis
* Apoptosome
* Bcl-2
* BH3 interacting domain death agonist (BID)
* Caspases
* Cytochrome c
* Noxa
* Mitochondrion
* p53 upregulated modulator of apoptosis (PUMA)

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vieira HL, Haouzi D, El Hamel C, "et al." |title=Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. |journal=Cell Death Differ. |volume=7 |issue= 12 |pages= 1146–54 |year= 2001 |pmid= 11175251 |doi= 10.1038/sj.cdd.4400778
*cite journal | author=Buytaert E, Callewaert G, Vandenheede JR, Agostinis P |title=Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum. |journal=Autophagy |volume=2 |issue= 3 |pages= 238–40 |year= 2007 |pmid= 16874066 |doi=
*cite journal | author=Steele AD, Yi CH |title=Neuromuscular denervation: Bax up against the wall in amyotrophic lateral sclerosis. |journal=J. Neurosci. |volume=26 |issue= 50 |pages= 12849–51 |year= 2007 |pmid= 17171827 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Bcl-2-associated X protein — Bcl 2–associated X protein Pour les articles homonymes, voir Bax. La Bcl 2–associated X protein (Bax) est une protéine pro apoptotique de la famille de Bcl 2. Elle est capable d induire l apoptose en se liant avec Bcl 2 pour former des dimères… …   Wikipédia en Français

  • Bcl-2–associated X Protein — Pour les articles homonymes, voir Bax. La Bcl 2–associated X protein (Bax) est une protéine pro apoptotique de la famille de Bcl 2. Elle est capable d induire l apoptose en se liant avec Bcl 2 pour former des dimères Bax Bcl 2 inactifs …   Wikipédia en Français

  • Bcl-2–associated x protein — Pour les articles homonymes, voir Bax. La Bcl 2–associated X protein (Bax) est une protéine pro apoptotique de la famille de Bcl 2. Elle est capable d induire l apoptose en se liant avec Bcl 2 pour former des dimères Bax Bcl 2 inactifs …   Wikipédia en Français

  • Bcl-2–associated X protein — Pour les articles homonymes, voir Bax. La Bcl 2–associated X protein (Bax) est une protéine pro apoptotique de la famille de Bcl 2. Elle est capable d induire l apoptose en se liant avec des copies d elle même. Bcl 2 peut inhiber Bax en formant… …   Wikipédia en Français

  • Bcl-2-associated death promoter — The Bcl 2 associated death promoter (BAD) protein is a pro apoptotic member of the Bcl 2 gene family which is involved in initiating apoptosis. It does not contain a C terminal transmembrane domain for outer mitochondrial membrane and nuclear… …   Wikipedia

  • Bcl-2-associated death promoter — BCL2 antagonist of cell death Größe 168 aa; 18,4 kDa Struktur Heterodimer Bezeichner …   Deutsch Wikipedia

  • Bcl-2 — is the prototype for a family of mammalian genes and the proteins they produce. They govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro apoptotic (Bax, BAD, Bak and Bok among others) or anti apoptotic (including Bcl …   Wikipedia

  • Protein C — Not to be confused with C peptide, C reactive protein, or protein kinase C. Protein C (inactivator of coagulation factors Va and VIIIa) Tertiary structure of human activated protein C (minus the Gla domain …   Wikipedia

  • bcl-3 — Oncogene associated with some cases of B cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I k B. Seems to interfere with binding of 50 kD subunit of NF k B to DNA …   Dictionary of molecular biology

  • Death-associated protein 6 — Death domain associated protein Identifiers Symbols DAXX; BING2; DAP6; EAP1; MGC126245; MGC126246 External IDs …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.