Factor D

Factor D
complement factor D (adipsin)
Factor D.jpg
Factor D in Homo sapiens [1]
Symbol CFD
Alt. symbols DF, PFD
Entrez 1675
HUGO 2771
OMIM 134350
RefSeq NM_001928
UniProt P00746
Other data
Locus Chr. 19 p13.3

Factor D also known as complement factor D(CFD) or adipsin a protein which in humans is encoded by the CFD gene.[2] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.



The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.[2]

Alternative pathway. ( 4. Is factor D cleaving B to Bb and Ba)

Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.[3]

Clinical significance

The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.


All members of the chymotrypsin family of serine proteases have very similar structures. In all cases, including factor D, there is two antiparallel β-barrel domains with each barrel containing six β-strands with the same typology in all enzymes. The major difference in backbone structure between Factor D and the other serine proteases of the chymotrpsin family is in the surface loops connecting the secondary structural elements. Factor D displays different conformations of major catalytic and substrate-binding residues typically found in the chrotrypsin family. These features suggest the catalytic activity of factor D is prohibited unless conformational changes are induced by a realignment.[4]


  1. ^ PDB 1HFD; Narayana SV, Carson M, el-Kabbani O, et al. (January 1994). "Structure of human factor D. A complement system protein at 2.0 A resolution". J. Mol. Biol. 235 (2): 695–708. doi:10.1006/jmbi.1994.1021. PMID 8289289. 
  2. ^ a b "Entrez Gene: CFD". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1675. 
  3. ^ Ronti T, Lupattelli G, Mannarino E (April 2006). "The endocrine function of adipose tissue: an update". Clin. Endocrinol. (Oxf) 64 (4): 355–65. doi:10.1111/j.1365-2265.2006.02474.x. PMID 16584505. Lay summary – medscape.com. 
  4. ^ Volanakis JE, Narayana SV (April 1996). "Complement factor D, a novel serine protease". Protein Sci. 5 (4): 553–64. doi:10.1002/pro.5560050401. PMC 2143395. PMID 8845746. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2143395. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Factor-X — Saltar a navegación, búsqueda Para el programa de televisión, véase Factor X (TV). Un wikipedista está trabajando actualmente en extender este artículo. Es posible que, a causa de ello, haya lagunas de contenido o deficiencias de formato. Por… …   Wikipedia Español

  • factor — FÁCTOR, factori, s.m. I. 1. Element, condiţie, împrejurare care determină apariţia unui proces, a unei acţiuni, a unui fenomen. 2. (mat.) Fiecare dintre termenii unei înmulţiri. ♢ Factor prim = fiecare dintre numerele prime prin care se împarte… …   Dicționar Român

  • Factor — Paradigmen: multiparadigmatisch Erscheinungsjahr: 2003 Designer: Slava Pestov Aktuelle Version: 0.94  (September 2010) …   Deutsch Wikipedia

  • Factor 5 — Saltar a navegación, búsqueda Factor 5, LLC Tipo Privada Fundación 1987 Sede San Rafael, California, Estados Unidos Administración …   Wikipedia Español

  • factor — aside from its technical senses, means ‘a fact or circumstance that contributes to a result’, and the notion of cause lies at the heart of its use, as in Gladstone s sentence (1878) The first factor in the making of a nation is its religion. A… …   Modern English usage

  • factor — fac·tor n [Medieval Latin, doer, maker, agent, from Latin, maker, from facere to do, make] 1: one who acts or transacts business for another: as a: a commercial agent who buys or sells goods for others on commission b: one that lends money to… …   Law dictionary

  • Factor 5 — LLC war eine deutsche und später US amerikanische Firma, die Computer und Videospiele entwickelte. Sie entstand aus der Hacker Gruppe The Light Circle und wurde 1987 in Köln als kleines Entwicklungsstudio für Computerspiele gegründet. Die 5 im… …   Deutsch Wikipedia

  • Factor — Saltar a navegación, búsqueda Un factor puede hacer referencia a: Factorización; operación matemática. Factorización de enteros Factor (lenguaje de programación) Factor X; grupo de superhéroes mutantes de Marvel Comics. Factor X (programa de… …   Wikipedia Español

  • Factor Rh — Saltar a navegación, búsqueda El Factor Rh es una proteína integral de la membrana aglutinógena que está presente en todas las células. Un 85% de la población tiene en esa proteína una estructura dominante, que corresponde a una determinada… …   Wikipedia Español

  • factor Rh — m. inmun. Factor Rhesus. Medical Dictionary. 2011. factor Rh …   Diccionario médico

  • FACTOR — may also refer to the Object Oriented programming requirements caputre acronym Functionality, Application domain, Conditions, Technology, Objects and Responsibility; FACTOR (the Foundation to Assist Canadian Talent on Records) is a private non… …   Wikipedia