ACVR1


ACVR1

Protbox
Name= Activin receptor type-1
Photo=
Caption=
Gene = HUGO code: [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:171 ACVR1]
Structure =
Review =
Type=Serine/Threonine receptor kinase
Functions=
Domains= GS domain, TS domain, S/T domain
Diseases=Fibrodysplasia ossificans progressiva (FOP) OMIM|135100
Taxa = "Homo sapiens"; homologs: many metazoan phyla
Cells = ubiquitous
Location =Plasma membrane
Catalytic_activity=ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactors=Magnesium or manganese
Enzyme_regulation=
Actions=
Agonists=
Antagonists=
Mods=
Names= Activin receptor type I, ACTR-I, Serine/threonine-protein kinase, receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I
Interactions=
Pages=

ACVR1 or ALK-2 transduces signals of BMPs. BMPs bind either ACVR2A/ACVR2B or a BMPR2 and then form a complex with ACVR1. These go on to recruit the R-SMADs SMAD1, SMAD2, SMAD3 or SMAD6cite journal |author=Inman GJ, Nicolás FJ, Callahan JF, "et al" |title=SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 |journal=Mol. Pharmacol. |volume=62 |issue=1 |pages=65–74 |year=2002 |pmid=12065756 |doi= |url=http://molpharm.aspetjournals.org/cgi/content/full/62/1/65] It is associated with fibrodysplasia ossificans progressiva. [cite journal |author=Shore EM, Xu M, Feldman GJ, "et al" |title=A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva |journal=Nat. Genet. |volume=38 |issue=5 |pages=525–7 |year=2006 |pmid=16642017 |doi=10.1038/ng1783 |url=http://www.nature.com/ng/journal/v38/n5/abs/ng1783.html]

References

Category:S/T domain


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Fibrodysplasia ossificans progressiva — Infobox Disease Name = Fibrodysplasia ossificans progressiva Caption = DiseasesDB = 8732 ICD10 = ICD10|M|61|1|m|60 ICD9 = ICD9|728.11 ICDO = OMIM = 135100 MedlinePlus = eMedicineSubj = derm eMedicineTopic = 609 MeshID = D009221 Fibrodysplasia… …   Wikipedia

  • Фибродисплазия — оссифицирующая прогрессирующая МКБ 10 M61.161.1 МКБ 9 728.11728.11 OMIM …   Википедия

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Guanylate cyclase — (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase or GC) is a lyase enzyme. Contents 1 Reaction 2 Types 3 Function …   Wikipedia

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Myostatin — Identifiers Symbols MSTN; GDF8 External IDs OMIM:  …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • Anti-Müllerian hormone — Identifiers Symbol AMH Entrez 268 HUGO …   Wikipedia

  • Titin — The three dimensional structure of a type I module from titin. PDB rendering based on 1bpv …   Wikipedia

  • PDK1 — Not to be confused with the master kinase PDK1, 3 phosphoinositide dependent protein kinase (PDPK1). Pyruvate dehydrogenase kinase, isozyme 1 Rendering based on PDB …   Wikipedia