CD11a

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene. PBB_Summary
section_title =
summary_text = ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. [cite web | title = Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3683| accessdate = ]

CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Efalizumab acts as an immunosuppressant by binding to CD11a.

ee also

* CD11c
* integrin
* leukocyte adhesion deficiency

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lub M, van Kooyk Y, Figdor CG |title=Ins and outs of LFA-1. |journal=Immunol. Today |volume=16 |issue= 10 |pages= 479–83 |year= 1995 |pmid= 7576051 |doi=
*cite journal | author=Dickeson SK, Santoro SA |title=Ligand recognition by the I domain-containing integrins. |journal=Cell. Mol. Life Sci. |volume=54 |issue= 6 |pages= 556–66 |year= 1998 |pmid= 9676575 |doi=
*cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=
*cite journal | author=Giblin PA, Lemieux RM |title=LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics. |journal=Curr. Pharm. Des. |volume=12 |issue= 22 |pages= 2771–95 |year= 2006 |pmid= 16918410 |doi=
*cite journal | author=Maurer D, Holter W, Majdic O, "et al." |title=CD27 expression by a distinct subpopulation of human B lymphocytes. |journal=Eur. J. Immunol. |volume=20 |issue= 12 |pages= 2679–84 |year= 1991 |pmid= 1702722 |doi=
*cite journal | author=Kalter DC, Gendelman HE, Meltzer MS |title=Inhibition of human immunodeficiency virus infection in monocytes by monoclonal antibodies against leukocyte adhesion molecules. |journal=Immunol. Lett. |volume=30 |issue= 2 |pages= 219–27 |year= 1992 |pmid= 1757107 |doi=
*cite journal | author=Alvarez V, Pulido R, Campanero MR, "et al." |title=Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils. |journal=Kidney Int. |volume=40 |issue= 5 |pages= 899–905 |year= 1992 |pmid= 1762294 |doi=
*cite journal | author=Valentin A, Lundin K, Patarroyo M, Asjö B |title=The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells. |journal=J. Immunol. |volume=144 |issue= 3 |pages= 934–7 |year= 1990 |pmid= 1967280 |doi=
*cite journal | author=Larson RS, Corbi AL, Berman L, Springer T |title=Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. |journal=J. Cell Biol. |volume=108 |issue= 2 |pages= 703–12 |year= 1989 |pmid= 2537322 |doi=
*cite journal | author=Hildreth JE, Orentas RJ |title=Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. |journal=Science |volume=244 |issue= 4908 |pages= 1075–8 |year= 1989 |pmid= 2543075 |doi=
*cite journal | author=Sanders ME, Makgoba MW, Sharrow SO, "et al." |title=Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. |journal=J. Immunol. |volume=140 |issue= 5 |pages= 1401–7 |year= 1988 |pmid= 2894392 |doi=
*cite journal | author=Corbi AL, Larson RS, Kishimoto TK, "et al." |title=Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. |journal=J. Exp. Med. |volume=167 |issue= 5 |pages= 1597–607 |year= 1988 |pmid= 3284962 |doi=
*cite journal | author=te Velde AA, Keizer GD, Figdor CG |title=Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells. |journal=Immunology |volume=61 |issue= 3 |pages= 261–7 |year= 1987 |pmid= 3301632 |doi=
*cite journal | author=Qu A, Leahy DJ |title=Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10277–81 |year= 1995 |pmid= 7479767 |doi=
*cite journal | author=Turner ML, McIlwaine K, Anthony RS, Parker AC |title=Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. |journal=Stem Cells |volume=13 |issue= 3 |pages= 311–6 |year= 1995 |pmid= 7542116 |doi=
*cite journal | author=Marzusch K, Ruck P, Geiselhart A, "et al." |title=Distribution of cell adhesion molecules on CD56++, CD3-, CD16- large granular lymphocytes and endothelial cells in first-trimester human decidua. |journal=Hum. Reprod. |volume=8 |issue= 8 |pages= 1203–8 |year= 1993 |pmid= 7691868 |doi=
*cite journal | author=Capobianchi MR, Ameglio F, Cordiali Fei P, "et al." |title=Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120. |journal=AIDS Res. Hum. Retroviruses |volume=9 |issue= 10 |pages= 957–62 |year= 1994 |pmid= 7904170 |doi=
*cite journal | author=Berman PW, Nakamura GR |title=Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation. |journal=AIDS Res. Hum. Retroviruses |volume=10 |issue= 5 |pages= 585–93 |year= 1994 |pmid= 7917519 |doi=
*cite journal | author=Chirmule N, Oyaizu N, Saxinger C, Pahwa S |title=Nef protein of HIV-1 has B-cell stimulatory activity. |journal=AIDS |volume=8 |issue= 6 |pages= 733–4 |year= 1994 |pmid= 8086129 |doi=

External links

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