- Angiopoietin
protein
Name = angiopoietin 1
caption =
width =
HGNCid = 484
Symbol = ANGPT1
AltSymbols =
EntrezGene = 284
OMIM = 601667
RefSeq = NM_001146
UniProt = Q15389
PDB =
ECnumber =
Chromosome = 8
Arm = q
Band = 22
LocusSupplementaryData = .3-8q23protein
Name = angiopoietin 2
caption =
width =
HGNCid = 485
Symbol = ANGPT2
AltSymbols =
EntrezGene = 285
OMIM = 601922
RefSeq = NM_001147
UniProt = O15123
PDB =
ECnumber =
Chromosome = 8
Arm = p
Band = 23
LocusSupplementaryData =The angiopoietins are
protein growth factors that promoteangiogenesis , the formation of blood vessels. There are now four identified angiopoietins:
Ang1, Ang2, Ang3, Ang4. Ang1 and Ang2 are required for the formation of mature blood vessels, as demonstrated by mouseknock out studies Thurston G. Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis. Cell Tissue Res. 2003 Oct;314(1):61-8. Epub 2003 Aug 12.] .Angiopoietin Receptors
The
Tie receptors aretyrosine kinases , so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating the binding and activation of downstream, intracellular enzymes; this process is calledcell signalling , and it is the method by which cells are induced to activate or inhibit key regulatory functions. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation - but it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietinsClinical Relevance
Angiopoietin 2 is elevated in patients with angiosarcoma (PMID 15149523)
References
External links
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