- Brodmann area 46
Brain: Brodmann area 46 Latin Area frontalis media NeuroLex ID birnlex_1778
BA46 is known as middle frontal area 46. In the human brain it occupies approximately the middle third of the middle frontal gyrus and the most rostral portion of the inferior frontal gyrus. Brodmann area 46 roughly corresponds with the dorsolateral prefrontal cortex (DLPFC), although the borders of area 46 are based on cytoarchitecture rather than function. The DLPFC also encompasses part of granular frontal area 9, directly adjacent on the dorsal surface of the cortex.
Cytoarchitecturally, BA46 is bounded dorsally by the granular frontal area 9, rostroventrally by the frontopolar area 10 and caudally by the triangular area 45 (Brodmann-1909). There is some discrepancy between the extent of BA8 (Brodmann-1905) and the same area as described by Walker (1940)
The DLPFC plays a role in sustaining attention and working memory. Lesions to the DLPFC impair short-term memory and cause difficulty inhibiting responses. Lesions may also eliminate much of the ability to make judgements about what's relevant and what's not as well as causing problems in organization.
The DLPFC has recently been found to be involved in exhibiting self-control. http://sciencenow.sciencemag.org/cgi/content/full/2009/501/3
The dorsolateral prefrontal cortex, which is one of the few areas deactivated during REM sleep. Neuroscientist J. Allan Hobson has hypothesized that activation of the dorsolateral prefrontal cortex produce lucid dreams.
- ^ Petrides, M., Pandya, D.M., (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience, Vol. 11, pp. 1011–1036
- Petrides, M., Pandya, D.M., (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience, Vol. 11, pp. 1011–1036
- For Neuroanatomy of the area visit BrainInfo
Human brain: forebrain (cerebrum · cerebral cortex · cerebral hemispheres, grey matter) (TA A14.1.09.002–240, 301–320, GA 9.818–826) Frontal lobeSuperolateralPrecentralPrecentral gyrus · Precentral sulcusMedial/inferiorPrecentralBoth Parietal lobeSuperolateralMedial/inferiorBoth Occipital lobeSuperolateralMedial/inferior Temporal lobeSuperolateralMedial/inferior Interlobar
Limbic lobeHippocampal formationOther Insular lobeLong gyrus of insula · Short gyri of insula · Circular sulcus of insula General Some categorizations are approximations, and some Brodmann areas span gyri.
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