Importin


Importin

Importin is a type of protein that moves other protein molecules into the nucleus by binding to a specific recognition sequence, called the nuclear localization signal (NLS). Importin is classified as a karyopherin. [http://big.mcw.edu/display.php/1053.html] cite journal | author = Görlich D, Prehn S, Laskey RA, Hartmann E | title = Isolation of a protein that is essential for the first step of nuclear protein import | journal = Cell | volume = 79 | issue = 5 | pages = 767–78 | year = 1994 | pmid = 8001116 | doi = 10.1016/0092-8674(94)90067-1 | issn = ]

Importin has two subunits, importin α and importin β. Of these, importin α binds to the NLS of the protein to be imported to the nucleus whereas importin β helps in the docking of the importin heterodimer-bound protein to the nuclear pore complex. The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus.cite journal | author = Mattaj IW, Englmeier L | title = Nucleocytoplasmic transport: the soluble phase | journal = Annu. Rev. Biochem. | volume = 67 | issue = | pages = 265–306 | year = 1998 | pmid = 9759490 | doi = 10.1146/annurev.biochem.67.1.265 | issn = ]

Genes

* Importin: Gene|IPO4, IPO7, Gene|IPO8, IPO9, Gene|IPO11, Gene|IPO13
* Karyopherin-α: KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6
* Karyopherin-β: KPNB1

References

External links

*


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Importin — Importine sind Proteinkomplexe in Eukaryoten, die den Transport von Proteinen vom Cytoplasma einer Zelle in ihren Zellkern erleichtern. Importine erkennen und binden die NLS Sequenz auf Proteinen und der so entstandene Komplex bindet seinerseits… …   Deutsch Wikipedia

  • importin — noun Any of various karyopherins that move other protein molecules into the cell nucleus by binding to a specific recognition sequence …   Wiktionary

  • IPO7 — Importin 7, also known as IPO7, is a human gene.cite web | title = Entrez Gene: IPO7 importin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10527| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • IPO11 — Importin 11, also known as IPO11, is a human gene.cite web | title = Entrez Gene: IPO11 importin 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51194| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • IPO4 — Importin 4, also known as IPO4, is a human gene.cite web | title = Entrez Gene: IPO4 importin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=79711| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • IPO9 — Importin 9, also known as IPO9, is a human gene.cite web | title = Entrez Gene: IPO9 importin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=55705| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • IPO13 — Importin 13, also known as IPO13, is a human gene.cite web | title = Entrez Gene: IPO13 importin 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9670| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • KPNB1 — Karyopherin (importin) beta 1 PDB rendering based on 1f59 …   Wikipedia

  • Nuclear localization sequence — A nuclear localization signal or sequence (NLS) is an amino acid sequence which tags a protein for import into the cell nucleus by nuclear transport. Typically, this signal consists of one or more short sequences of positively charged lysines or… …   Wikipedia

  • Nuclear localization signal — A nuclear localizing sequence (NLS) is an amino acid sequence which acts like a tag on the exposed surface of a protein. This sequence is used to target the protein to the cell nucleus through the Nuclear Pore Complex and to direct a newly… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.