Karyopherin


Karyopherin

Karyopherins are a group of proteins involved in transporting molecules through the pores of the nuclear envelope (the membrane around a cell's nucleus).

Karyopherins, which may act as "importins" or "exportins", are part of the Importin-β super-family which all share a similar three-dimensional structure.

They belong to [http://www.tcdb.org/tcdb/index.php?tc=9.A.14 9.A.14 The Nuclear Pore Complex Family] in TCDB.

Cycle

For example,
*importin beta + adapter + cargo protein (cytoplasm)-->(karyoplasm)
*importin beta + adapter + RanGTP (karyoplasm)-->(cytoplasm)
*Ran-GTP --> RanGDP + P

Genes

* KPNA1
* KPNA2
* KPNA3
* KPNA4
* KPNA5
* KPNA6
* KPNB1
* KPNB2


=Additional

External links

*
* [http://jkweb.berkeley.edu/external/pdb/1998/kap_alpha/kap_alpha.html Illustrations at berkeley.edu]
* [http://sspatel.googlepages.com/nuclearporecomplex Karyopherin animations]
* [http://sspatel.googlepages.com/nuclearporecomplex2 Karyopherin illustrations]


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Look at other dictionaries:

  • karyopherin — noun Any of a group of proteins, classified as importins and exportins, involved in transporting molecules through the pores of the nuclear envelope …   Wiktionary

  • Karyopherin alpha 1 — (importin alpha 5) PDB rendering based on 2jdq …   Wikipedia

  • KPNB1 — Karyopherin (importin) beta 1 PDB rendering based on 1f59 …   Wikipedia

  • KPNA1 — Karyopherin alpha 1 (importin alpha 5), also known as KPNA1, is a human gene. PBB Summary section title = summary text = Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for… …   Wikipedia

  • KPNA3 — Karyopherin alpha 3 (importin alpha 4), also known as KPNA3, is a human gene. PBB Summary section title = summary text = The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex… …   Wikipedia

  • KPNA2 — Karyopherin alpha 2 (RAG cohort 1, importin alpha 1), also known as KPNA2, is a human gene. PBB Summary section title = summary text = The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy… …   Wikipedia

  • KPNA4 — Karyopherin alpha 4 (importin alpha 3), also known as KPNA4, is a human gene. PBB Summary section title = summary text = The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals… …   Wikipedia

  • KPNA5 — Karyopherin alpha 5 (importin alpha 6), also known as KPNA5, is a human gene. PBB Summary section title = summary text = The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex… …   Wikipedia

  • KPNA6 — Karyopherin alpha 6 (importin alpha 7), also known as KPNA6, is a human gene. PBB Summary section title = summary text = Nucleocytoplasmic transport, a signal and energy dependent process, takes place through nuclear pore complexes embedded in… …   Wikipedia

  • NUP98 — Nucleoporin 98kDa PDB rendering based on 1ko6 …   Wikipedia


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