Dyslipidemia is a disruption in the amount of lipids in the blood.

In western societies, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dylipidaemia. [http://www.nature.com/nature/journal/v451/n7181/edsumm/e080221-09.html]


There are two major ways in which dyslipidemias are classified:

* Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
* Etiology, or the reason for the condition (genetic, or secondary to another condition.) This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well defined genetic conditions that are usually easy to identify.

Fredrickson Classification:



:"These conditions are discussed in greater detail at hyperlipidemia."

* Hyperlipidemia: lipids
** Hypercholesterolemia: cholesterol
** Hyperglyceridemia: glycerides
*** Hypertriglyceridemia: triglycerides
* Hyperlipoproteinemia: lipoproteins (usually LDL unless otherwise specified)
** Hyperchylomicronemia: chylomicrons
* Combined hyperlipidemia: both LDL and triglycerides

Familial hypercholesterolemia is a specific form of hypercholesterolemia due to a defect on chromosome 19 (19p13.1-13.3).


* Hypolipoproteinemia: lipoproteins
* Hypocholesterolemia: cholesterol
* Abetalipoproteinemia: beta lipoproteins
* Tangier disease: high density lipoprotein


Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • dyslipidemia — noun an excess of lipids (especially cholesterol) in the blood; hypercholesterolemia …   Wiktionary

  • dyslipidemia — dys·lip·id·emia or chiefly Brit dys·lip·id·ae·mia dis .lip ə dē mē ə n a condition marked by abnormal concentrations of lipids or lipoproteins in the blood dys·lip·id·emic or chiefly Brit dys·lip·id·ae·mic mik adj * * * dys·lip·id·e·mia (dis… …   Medical dictionary

  • mixed dyslipidemia — mixed hyperlipemia …   Medical dictionary

  • Metabolic syndrome — Dysmetabolic syndrome X Classification and external resources An obese male. Weight 146 kg/322 lbs, height 177 cm/5 ft 10 in. The body mass index is 46. ICD 9 …   Wikipedia

  • Fenofibrate — Systematic (IUPAC) name propan 2 yl 2 {4 [(4 chlorophenyl)carbonyl]phenoxy} 2 methylpropanoate Clinical data Trade names …   Wikipedia

  • Pre-diabetes — is a relatively new term for a condition of abnormal glucose metabolism wherein the patient has periods of both hyper and hypo glycemia, but without meeting the formal definition of type 2 diabetes mellitus. An individual may show evidence of… …   Wikipedia

  • Lipid — Structures of some common lipids. At the top are oleic acid[1] and cholesterol.[2] The middle structure is a triglyceride composed of oleoyl, stearoyl, and palmitoyl chains at …   Wikipedia

  • Niacin — IUPAC name …   Wikipedia

  • Peripheral vascular disease — Classification and external resources ICD 10 I73.9 …   Wikipedia

  • Rosuvastatin — Systematic (IUPAC) name …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.