Tolfenamic acid


Tolfenamic acid
Tolfenamic acid
Systematic (IUPAC) name
2-[(3-chloro-2-methylphenyl)amino]benzoic acid)[1]
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes oral
Identifiers
CAS number 13710-19-5 YesY
ATC code M01AG02
PubChem CID 610479
ChemSpider 530683 YesY
UNII 3G943U18KM N
KEGG D01183 N
ChEMBL CHEMBL121626 N
Chemical data
Formula C14H12ClNO2 
Mol. mass 261.707 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  acid (verify)

Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.

Contents

Other possible uses

A study concludes, "TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p<0.001) and in reducing the reported hangover symptoms in general (p < 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p<0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p < 0.05)."[1]

Commercial names

Commercial names for tolfenamic acid include Clotam Rapid and Tufnil for use in humans and Tolfedine for veterinary use in cats and dogs. This drug should not be confused with Tolmetin.

References

  1. ^ a b Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). = P29890001443 "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443. http://www.rsc.org/Publishing/Journals/P2/article.asp?doi = P29890001443. 

External links



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