- Arbidol
drugbox
width=200
IUPAC_name = 1-methyl-2-((phenylthio)methyl)-3-
carbethoxy-4-((dimethylamino)methyl)-5-
hydroxy-6-bromindole hydrochloride
CAS_number = 131707-23-8
PubChem= 131410
ATC_prefix= L03
ATC_suffix= AX
DrugBank=N/A
C=22 | H=28 | Br=1 | Cl=1 | N=2 | O=4 | S=1
molecular_weight = 531.891 g/mol
bioavailability = N/A
metabolism = N/A-|elimination_half-life = 17–21 hours
excretion =renal
pregnancy_category = N/A
legal_status = N/A
routes_of_administration =Arbidol ( _ru. Арбидол) is an
antiviral drug manufactured by Masterlek inMoscow ,Russia .Chemically, Arbidol features an
indole core, functionalized at all positions but one with different substituents.Uses
It is an alternative to
Tamiflu (manufactured byRoche Pharmaceuticals ) used in the fight againstavian influenza . Its antiviral inhibitory effect is still being tested and the current results range from being well accepted inpharmaceutical industry to accepted with a dose of suspicion.The drug has mainly been tested and used in
Russia [cite journal |author=Leneva IA, Fediakina IT, Gus'kova TA, Glushkov RG |title= [Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A] |language=Russian |journal=Ter. Arkh. |volume=77 |issue=8 |pages=84–8 |year=2005 |pmid=16206613 |doi=] andChina , [cite journal |author=Wang MZ, Cai BQ, Li LY, "et al" |title= [Efficacy and safety of arbidol in treatment of naturally acquired influenza] |language=Chinese |journal=Zhongguo Yi Xue Ke Xue Yuan Xaue Bao |volume=26 |issue=3 |pages=289–93 |year=2004 |pmid=15266832 |doi=] and has been shown to be effective against avian flu,cite web |url=http://arbidol.org/arbidol-2005-works-as-well.html |title=Works as well as Tamiflu |accessdate=2008-02-22 |format= |work=] suggesting it might be a more affordable and cost-effective drug than the widely used Tamiflu.There is some evidence that it may be more effective at preventing infections from
RNA virus es than fromDNA virus es.cite journal |author=Shi L, Xiong H, He J, "et al" |title=Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo |journal=Arch. Virol. |volume=152 |issue=8 |pages=1447–55 |year=2007 |pmid=17497238 |doi=10.1007/s00705-007-0974-5]It has also been investigated as a candidate drug against
hepatitis C .cite journal |author=Pécheur EI, Lavillette D, Alcaras F, "et al" |title=Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol |journal=Biochemistry |volume=46 |issue=20 |pages=6050–9 |year=2007 |pmid=17455911 |doi=10.1021/bi700181j]Mechanism of action
The drug exhibits
immunomodulation cite journal |author=Glushkov RG, Gus'kova TA, Krylova LIu, Nikolaeva IS |title= [Mechanisms of arbidole's immunomodulating action] |language=Russian |journal=Vestn. Akad. Med. Nauk SSSR |volume= |issue=3 |pages=36–40 |year=1999 |pmid=10222830 |doi=] as well as a specific anti-influenza action against theinfluenza A andinfluenza B viruses.It prevents contact between the
virus and host cells and penetration of virus particles into the cell by inhibiting the fusion of the viruslipid shell to thecell membrane s. cite journal |author=Boriskin YS, Pécheur EI, Polyak SJ |title=Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection |journal=Virol. J. |volume=3 |issue= |pages=56 |year=2006 |pmid=16854226 |doi=10.1186/1743-422X-3-56 |url=http://www.virologyj.com/content/3//56]It possesses
interferon inducing action, by stimulating thehumoral reaction and the phagocytic function ofmacrophage s.Dosage forms
The drug is manufactured in the form of
tablet s andcapsule s, each tablet containing Arbidol as itsactive ingredient (50 mg and 100 mg).Pharmacokinetics and usage
Side effects in children include sensitization to the drug. No known overdose cases have been reported and
allergic reactions are limited to people withhypersensitivity .References
External links
* "Мастерлек" Pharmaceuticals, Moscow, Russia. Patent number № 2033157, Registry number № 003610/01.
*
* [http://www.arbidol.ru/ Arbidol]
* [http://www.arbidol.org/ English Translations for Arbidol clinical studies 1973–2007]
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