Bone morphogenetic protein 5

Bone morphogenetic protein 5, also known as BMP5, is a human gene.cite web | title = Entrez Gene: BMP5 bone morphogenetic protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653| accessdate = ]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.cite web | title = Entrez Gene: BMP5 bone morphogenetic protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hahn GV, Cohen RB, Wozney JM, "et al." |title=A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. |journal=Genomics |volume=14 |issue= 3 |pages= 759–62 |year= 1992 |pmid= 1427904 |doi=
*cite journal | author=Celeste AJ, Iannazzi JA, Taylor RC, "et al." |title=Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9843–7 |year= 1991 |pmid= 2263636 |doi=
*cite journal | author=Sakaue M, Kitazawa S, Nishida K, "et al." |title=Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 3 |pages= 768–72 |year= 1996 |pmid= 8630036 |doi= 10.1006/bbrc.1996.0671
*cite journal | author=You L, Kruse FE, Pohl J, Völcker HE |title=Bone morphogenetic proteins and growth and differentiation factors in the human cornea. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 2 |pages= 296–311 |year= 1999 |pmid= 9950587 |doi=
*cite journal | author=Imai N, Iwai A, Hatakeyama S, "et al." |title=Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification. |journal=Pathol. Int. |volume=51 |issue= 8 |pages= 643–8 |year= 2001 |pmid= 11564221 |doi=
*cite journal | author=Beck HN, Drahushuk K, Jacoby DB, "et al." |title=Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. |journal=BMC neuroscience |volume=2 |issue= |pages= 12 |year= 2003 |pmid= 11580864 |doi=
*cite journal | author=Jin Y, Lu HB, Liong E, "et al." |title=Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. |journal=Histol. Histopathol. |volume=16 |issue= 4 |pages= 1013–9 |year= 2002 |pmid= 11642720 |doi=
*cite journal | author=Cohen A, Mulas R, Seri M, "et al." |title=Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes. |journal=Am. J. Med. Genet. |volume=107 |issue= 1 |pages= 48–51 |year= 2002 |pmid= 11807867 |doi=
*cite journal | author=Jiang FX, Stanley EG, Gonez LJ, Harrison LC |title=Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. |journal=J. Cell. Sci. |volume=115 |issue= Pt 4 |pages= 753–60 |year= 2002 |pmid= 11865031 |doi=
*cite journal | author=Luo J, Dunn T, Ewing C, "et al." |title=Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis. |journal=Prostate |volume=51 |issue= 3 |pages= 189–200 |year= 2002 |pmid= 11967953 |doi= 10.1002/pros.10087
*cite journal | author=Wordinger RJ, Agarwal R, Talati M, "et al." |title=Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. |journal=Mol. Vis. |volume=8 |issue= |pages= 241–50 |year= 2002 |pmid= 12131877 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Nakayama N, Han CY, Cam L, "et al." |title=A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. |journal=Development |volume=131 |issue= 1 |pages= 229–40 |year= 2004 |pmid= 14660436 |doi= 10.1242/dev.00901
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Xu WP, Shiba H, Mizuno N, "et al." |title=Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. |journal=Cell Biol. Int. |volume=28 |issue= 10 |pages= 675–82 |year= 2005 |pmid= 15516325 |doi= 10.1016/j.cellbi.2004.06.004
*cite journal | author=Bobinac D, Marić I, Zoricić S, "et al." |title=Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer. |journal=Croat. Med. J. |volume=46 |issue= 3 |pages= 389–96 |year= 2005 |pmid= 15861517 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Bramlage CP, Häupl T, Kaps C, "et al." |title=Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. |journal=Arthritis Res. Ther. |volume=8 |issue= 3 |pages= R58 |year= 2006 |pmid= 16542506 |doi= 10.1186/ar1923
*cite journal | author=Wilkins JM, Southam L, Price AJ, "et al." |title=Extreme context specificity in differential allelic expression. |journal=Hum. Mol. Genet. |volume=16 |issue= 5 |pages= 537–46 |year= 2007 |pmid= 17220169 |doi= 10.1093/hmg/ddl488

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