Bone morphogenetic protein 15

Bone morphogenetic protein 15, also known as BMP15, is a human gene.cite web | title = Entrez Gene: BMP15 bone morphogenetic protein 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9210| accessdate = ]

The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dube JL, Wang P, Elvin J, "et al." |title=The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1809–17 |year= 1999 |pmid= 9849956 |doi=
*cite journal | author=Aaltonen J, Laitinen MP, Vuojolainen K, "et al." |title=Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 8 |pages= 2744–50 |year= 1999 |pmid= 10443672 |doi=
*cite journal | author=Galloway SM, McNatty KP, Cambridge LM, "et al." |title=Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 279–83 |year= 2000 |pmid= 10888873 |doi= 10.1038/77033
*cite journal | author=Otsuka F, Yao Z, Lee T, "et al." |title=Bone morphogenetic protein-15. Identification of target cells and biological functions. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39523–8 |year= 2001 |pmid= 10998422 |doi= 10.1074/jbc.M007428200
*cite journal | author=Otsuka F, Moore RK, Iemura S, "et al." |title=Follistatin inhibits the function of the oocyte-derived factor BMP-15. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 5 |pages= 961–6 |year= 2002 |pmid= 11741284 |doi= 10.1006/bbrc.2001.6103
*cite journal | author=Moore RK, Otsuka F, Shimasaki S |title=Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 304–10 |year= 2003 |pmid= 12419820 |doi= 10.1074/jbc.M207362200
*cite journal | author=Liao WX, Moore RK, Otsuka F, Shimasaki S |title=Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3713–9 |year= 2003 |pmid= 12446716 |doi= 10.1074/jbc.M210598200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liao WX, Moore RK, Shimasaki S |title=Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17391–6 |year= 2004 |pmid= 14970198 |doi= 10.1074/jbc.M401050200
*cite journal | author=Di Pasquale E, Beck-Peccoz P, Persani L |title=Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. |journal=Am. J. Hum. Genet. |volume=75 |issue= 1 |pages= 106–11 |year= 2004 |pmid= 15136966 |doi= 10.1086/422103
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Hashimoto O, Moore RK, Shimasaki S |title=Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 15 |pages= 5426–31 |year= 2005 |pmid= 15809424 |doi= 10.1073/pnas.0409533102
*cite journal | author=Dixit H, Rao LK, Padmalatha VV, "et al." |title=Missense mutations in the BMP15 gene are associated with ovarian failure. |journal=Hum. Genet. |volume=119 |issue= 4 |pages= 408–15 |year= 2006 |pmid= 16508750 |doi= 10.1007/s00439-006-0150-0
*cite journal | author=Laissue P, Christin-Maitre S, Touraine P, "et al." |title=Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. |journal=Eur. J. Endocrinol. |volume=154 |issue= 5 |pages= 739–44 |year= 2006 |pmid= 16645022 |doi= 10.1530/eje.1.02135
*cite journal | author=Chand AL, Ponnampalam AP, Harris SE, "et al." |title=Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure. |journal=Fertil. Steril. |volume=86 |issue= 4 |pages= 1009–12 |year= 2006 |pmid= 17027369 |doi= 10.1016/j.fertnstert.2006.02.107

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