Cyclin E


Cyclin E
cyclin E1
Identifiers
Symbol CCNE1
Alt. symbols CCNE
Entrez 898
HUGO 1589
OMIM 123837
RefSeq NM_001238
UniProt P24864
Other data
Locus Chr. 19 q12
cyclin E2
Identifiers
Symbol CCNE2
Entrez 9134
HUGO 1590
OMIM 603775
RefSeq NM_057749
UniProt O96020
Other data
Locus Chr. 8 q22.1

Cyclin E is a member of the cyclin family.

Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.

Expression of cyclins through the cell cycle.

External links


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Look at other dictionaries:

  • Cyclin D — cyclin D1 Crystal structure of human cyclin D1 (blue/green) in complex with cyclin dependent kinase 4 (yellow/red).[1] Identifiers …   Wikipedia

  • Cyclin A2 — PDB rendering based on 1e9h …   Wikipedia

  • Cyclin B1 — PDB rendering based on 2b9r …   Wikipedia

  • Cyclin A1 — Identifiers Symbols CCNA1; External IDs OMIM:  …   Wikipedia

  • Cyclin E1 — PDB rendering based on 1w98 …   Wikipedia

  • Cyclin D3 — Identifiers Symbols CCND3; External IDs OMIM:  …   Wikipedia

  • Cyclin H — PDB rendering based on 1jkw …   Wikipedia

  • Cyclin D2 — Identifiers Symbols CCND2; KIAK0002; MGC102758 External IDs OMIM:  …   Wikipedia

  • Cyclin T2 — PDB rendering based on 2ivx …   Wikipedia

  • Cyclin B2 — Identifiers Symbols CCNB2; HsT17299 External IDs OMIM:  …   Wikipedia

  • Cyclin T1 — Rendering based on PDB 2PK2 …   Wikipedia


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