Cyclin B

Cyclin B
Structure of PDB 2B9R human cyclin B rendered with PyMol (DeLano Scientific Freeware).
Structure of human cyclin B.[1]
cyclin B1
Symbol CCNB1
Alt. symbols CCNB
Entrez 891
HUGO 1579
OMIM 123836
RefSeq NM_031966
UniProt P14635
Other data
Locus Chr. 5 q12
cyclin B2
Symbol CCNB2
Entrez 9133
HUGO 1580
OMIM 602755
RefSeq NM_004701
UniProt O95067
Other data
Locus Chr. 15 q21.3
cyclin B3
Symbol CCNB3
Entrez 85417
HUGO 18709
OMIM 300456
RefSeq NM_033670
UniProt Q8WWL7
Other data
Locus Chr. X p11

Cyclin B is a member of the cyclin family.

Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle[2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present).[3] The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).

Expression of cyclins through the cell cycle.

See also


  1. ^ Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. (2007). "The crystal structure of human cyclin B". Cell Cycle 11 (11): 1342–9. PMID 17495533. 
  2. ^ Ito M (August 2000). "Factors controlling cyclin B expression". Plant Mol. Biol. 43 (5-6): 677–90. doi:10.1023/A:1006336005587. PMID 11089869. 
  3. ^ Hershko A (September 1999). "Mechanisms and regulation of the degradation of cyclin B". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 354 (1389): 1571–5; discussion 1575–6. doi:10.1098/rstb.1999.0500. PMC 1692665. PMID 10582242. 

External links

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