Acyl CoA dehydrogenase

Acyl CoA dehydrogenase

Acyl CoA dehydrogenase is the enzyme used to catalyze the first step of β-oxidation in Fatty acid metabolism.

Reaction

The following reaction is the oxidation of the fatty acid by FAD.

The enzyme catalyzes the formation of a double bond between the C-2 and C-3. The end product is trans-Δ2-enoyl-CoA.

It is classified as EC number|1.3.99.3.

Proteins

It is made up of the following proteins:

Several of the units are classified by length, and some of those are associated with a particular metabolic disorder:

Other subunits include Gene|ACAD8, Gene|ACAD9, Gene|ACAD10 and Gene|ACAD11.

ee also

* Acyl CoA

External links

*


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См. также в других словарях:

  • acyl-CoA dehydrogenase — ac·yl CoA de·hy·dro·gen·ase (aґsəl ko aґ de hiґdro jən ās) [EC 1.3.99.3] any of several enzymes of the oxidoreductase class that catalyze the oxidation of acyl coenzyme A thioesters to the enoyl coenzyme A form, using a flavin… …   Medical dictionary

  • Acyl-CoA dehydrogenase (NADP+) — In enzymology, an acyl CoA dehydrogenase (NADP+) (EC number|1.3.1.8) is an enzyme that catalyzes the chemical reaction:acyl CoA + NADP+ ightleftharpoons 2,3 dehydroacyl CoA + NADPH + H+Thus, the two substrates of this enzyme are acyl CoA and… …   Wikipedia

  • Medium-Chain-Acyl-CoA-Dehydrogenase-Mangel — Klassifikation nach ICD 10 E71.3 Störungen des Fettsäurestoffwechsels …   Deutsch Wikipedia

  • Long-chain-acyl-CoA dehydrogenase — In enzymology, a long chain acyl CoA dehydrogenase (EC number|1.3.99.13) is an enzyme that catalyzes the chemical reaction:acyl CoA + acceptor ightleftharpoons 2,3 dehydroacyl CoA + reduced acceptorThus, the two substrates of this enzyme are acyl …   Wikipedia

  • long-chain acyl-CoA dehydrogenase — See acyl CoA dehydrogenase (NADPH) …   Medical dictionary

  • medium-chain acyl-CoA dehydrogenase — See acyl CoA dehydrogenase (NADPH) …   Medical dictionary

  • short-chain acyl-CoA dehydrogenase — See acyl CoA dehydrogenase (NADPH) …   Medical dictionary

  • long-chain acyl-CoA dehydrogenase (LCAD) deficiency — a defect in mitochondrial beta oxidation due to a mutation in the gene (locus: 2q34 q35) encoding the acyl CoA dehydrogenase that acts on long chain length fatty acids. It is clinically similar to MCAD deficiency, but urinary excretion is of long …   Medical dictionary

  • medium-chain acyl-CoA dehydrogenase (MCAD) deficiency — a defect in mitochondrial beta oxidation due to a mutation in the gene (locus: 1p31) encoding acyl CoA dehydrogenase that acts on medium chain length fatty acids. It is characterized by recurring episodes of hypoglycemia, vomiting, and lethargy,… …   Medical dictionary

  • short-chain acyl-CoA dehydrogenase (SCAD) deficiency — a defect in mitochondrial beta oxidation due to a mutation in the gene (locus: 12q22 qter) encoding the acyl CoA dehydrogenase that acts on short chain length fatty acids. Clinical presentation is variable, but myopathy and abnormalities of… …   Medical dictionary


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