Aquaporin 4

Aquaporin 4

protein
Name=aquaporin 4
caption=


width=
HGNCid=637
Symbol=AQP4
AltSymbols=
EntrezGene=361
OMIM=600308
RefSeq=NM_001650
UniProt=P55087
PDB=
ECnumber=
Chromosome=18
Arm=q
Band=11.2
LocusSupplementaryData=-12.1

Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.cite journal | author = Agre P, Nielsen S | title = The aquaporin family of water channels in kidney | journal = Nephrologie | volume = 17 | issue = 7 | pages = 409–15 | year = 1996 | pmid = 8987045 | doi = | issn = ]

AQP4 is constitutively expressed.

AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system.cite journal | author = Nagelhus EA, Mathiisen TM, Ottersen OP | title = Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1 | journal = Neuroscience | volume = 129 | issue = 4 | pages = 905–13 | year = 2004 | pmid = 15561407 | doi = 10.1016/j.neuroscience.2004.08.053 | issn = ]

Pathology

It is the autoimmune target in Devic's disease.

ee also

* Aquaporins

References

External links

*


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Look at other dictionaries:

  • Aquaporin — Aquaporins are integral membrane proteins from a larger family of major intrinsic proteins (MIP) that form pores in the membrane of biological cells.cite journal | author = Agre P | title = The aquaporin water channels | journal = Proc Am Thorac… …   Wikipedia

  • Aquaporin 2 — AQP2 is found in the apical cell membranes of the kidney s collecting duct principal cells and in intracellular vesicles located throughout the cell. RegulationIt is the only aquaporin regulated by vasopressin.cite journal |author=Dibas AI, Mia… …   Wikipedia

  • Aquaporin 1 — AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of… …   Wikipedia

  • Aquaporin — Aquaporine Bänderdarstellung des AQP1 …   Deutsch Wikipedia

  • Aquaporin 3 — protein Name=aquaporin 3 (Gill blood group) caption= width= HGNCid=636 Symbol=AQP3 AltSymbols= EntrezGene=360 OMIM=600170 RefSeq=NM 004925 UniProt=Q92482 PDB= ECnumber= Chromosome=9 Arm=p Band=13 LocusSupplementaryData=Aquaporin 3 is found in the …   Wikipedia

  • aquaporin — (= AQP; CHIP28) Integral membrane protein (28 kD) with six trans membrane domains that greatly increases water permeability. Found esp. in kidney, red blood cells. AQP1 forms a homotetramer of four independent channels. Arabidopsis has at least… …   Dictionary of molecular biology

  • aquaporin — noun Any of a class of proteins that form pores in the membrane of biological cells …   Wiktionary

  • aquaporin — aqua·po·rin (ak″wə poґrin) any of a family of proteins, composed of four identical 28 kD subunits surrounding a central, water permeable pore and found in the plasma membranes of plant and animal cells, that permit passage of water and …   Medical dictionary

  • AQP — aquaporin …   Medical dictionary

  • water channel — aquaporin …   Medical dictionary

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