Aquaporin 4


Aquaporin 4

protein
Name=aquaporin 4
caption=


width=
HGNCid=637
Symbol=AQP4
AltSymbols=
EntrezGene=361
OMIM=600308
RefSeq=NM_001650
UniProt=P55087
PDB=
ECnumber=
Chromosome=18
Arm=q
Band=11.2
LocusSupplementaryData=-12.1

Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.cite journal | author = Agre P, Nielsen S | title = The aquaporin family of water channels in kidney | journal = Nephrologie | volume = 17 | issue = 7 | pages = 409–15 | year = 1996 | pmid = 8987045 | doi = | issn = ]

AQP4 is constitutively expressed.

AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system.cite journal | author = Nagelhus EA, Mathiisen TM, Ottersen OP | title = Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1 | journal = Neuroscience | volume = 129 | issue = 4 | pages = 905–13 | year = 2004 | pmid = 15561407 | doi = 10.1016/j.neuroscience.2004.08.053 | issn = ]

Pathology

It is the autoimmune target in Devic's disease.

ee also

* Aquaporins

References

External links

*


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Look at other dictionaries:

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