Immunophilins

Immunophilins

In molecular biology, immunophilins are peptidyl-prolyl isomerases that intraconvert between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as rapamycin, cyclosporin, and FK-506. For these drugs in particular, known immunophilins such as cyclophilin catalyze the "cis-trans" isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs.

ee also

* Cyclophilin
* FKBP52

External links

*
* [http://pmb.berkeley.edu/faculty/faculty_pages/Luan.html "Plant immunophilins and signal transduction" at berkeley.edu]


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • immunophilins — High affinity receptor proteins in the cytoplasm that combine with immunosuppressant drugs leading to rotamase inhibition and, in T cells, thus to interruption of cell activation. [immune + G. philos, fond, + in] …   Medical dictionary

  • FKBP52 — FK506 binding protein 4, 59kDa, also known as FKBP4, is a human gene.cite web | title = Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2288| accessdate = ] …   Wikipedia

  • Cyclophilin — peptidylprolyl isomerase A (cyclophilin A) Ribbon diagram of cyclophilin A in complex with ciclosporin (yellow). From PDB 1CWA …   Wikipedia

  • Immunosuppressive drug — For a list of immunosuppressive drugs, see the transplant rejection page .Immunosuppressive drugs, immunosuppressive agents, or immunosuppressants are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive …   Wikipedia

  • Stuart Schreiber — Stuart L. Schreiber (b. February 6, 1956) is a scientist at Harvard University and the Broad Institute of Harvard and MIT. He has been a pioneer in a field of research named chemical biology for over 20 years. His name is closely associated with… …   Wikipedia

  • FKBP5 — FK506 binding protein 5, also known as FKBP5, is a human gene.cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2289| accessdate = ] PBB Summary… …   Wikipedia

  • GLMN — Glomulin, FKBP associated protein, also known as GLMN, is a human gene.cite web | title = Entrez Gene: GLMN glomulin, FKBP associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=11146|… …   Wikipedia

  • Inmunofilina — Las inmunofilinas son peptidil prolil isomerasas que catalizan la transformación entre las posiciones cis y trans. Las inmunofilinas son una diana de fármacos inmunosupresores como la rapamicina, la ciclosporina y el tacrolimus. Para estos… …   Wikipedia Español

  • Chaperone (protein) — A top view of the GroES/GroEL bacterial chaperone complex model In molecular biology, chaperones are proteins that assist the non covalent folding or unfolding and the assembly or disassembly of other macromolecular structures, but do not occur… …   Wikipedia

  • Pattern recognition receptor — Pattern recognition receptors (PRRs) are a primitive part of the immune system. They are proteins expressed by cells of the innate immune system to identify pathogen associated molecular patterns (PAMPs), which are associated with microbial… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”