- No effect concentration
No effect concentration (NEC) is a
risk assessmentparameter that represents the concentrationof a pollutantthat will not harm the speciesinvolved, with respect to the effect that is studied. It is often the starting point for environmental policy[Bruijn et al, 1997, Chen & Selleck 1969] . Industryis continually synthesizing new chemicals, the regulation of which requires evaluation of the potential danger for human healthand the environment. Risk assessment is nowadays considered essential for making these decisions on a scientifically sound basis.
There is not much debate on the existence of an NEC [Van Straalen 1997, Crane and Newman 2000] but the assignment of a value is another matter. Current practice consists of the use of standard tests, which were developed in the 1970s. In the standard tests groups of animals are exposed to different concentrations of
chemicals and different effects such as survival, growth or reproductionare monitored. These toxicity tests typically result in a No Observed Effect Concentration (NOEC). This NOEC has been severely criticized on statistical grounds by several authors [Suter 1996, Laskowski 1995, [http://www.bio.vu.nl/thb/research/bib/Kooy96.html Kooijman 1996] , Van der Hoeven 1997] and it was concluded that the NOEC should be abandoned [ [http://www.oecd.org/document/30/0,2340,en_2649_34365_1916638_1_1_1_1,00.html OECD Document No 54 of "Series on Testing Assessment", 2006] ] . A proposed alternative is the use of so called ECx –concentrations, or the concentrating showing x % Effect (e.g. an EC5 in a survival experiment indicates the concentration where 5 % of the test animals would die in that experiment). ECx concentrations also have their problems in applying them to risk assessment. Any other value for x other than zero means an effect is accepted, this is in conflict with the aim of protecting the environment [Bruijn et. al 1997] . The aim of environmental legislation is to achieve no effect of pollutants to the environment. In addition ECx values do depend on the exposure time [Kooijman 1981, [http://www.bio.vu.nl/thb/research/bib/JageHeug2006.html Jager et al 2006] ] , it is essential to realize that ECx values decrease for increasing exposure time, until equilibrium has been established. This is because effects depend on internal concentrations [Kooijman 1981, Péry et al 2001a] , and that it takes time for the compound to penetrate the body of test organisms. The standard is to start with organisms that were not previously exposed to the compound. The exposure period during which the decrease is substantial depends on the properties of the test compound and of the organism and the type of effect. This may lead to the situation that an EC50 might be lower than an EC10 concentration depending on the test protocol used. It is clear that for the protection of the environment this is a non workable situation.
Therefore a biology based approach must be chosen [ [http://www.oecd.org/document/30/0,2340,en_2649_34365_1916638_1_1_1_1,00.html OECD Document No 54 of "Series on Testing Assessment", 2006] ] . Biology-based methods not only aim to describe observed effects, but also to understand them in terms of underlying processes such as toxico-kinetics, mortality, feeding, growth and reproduction (Kooijman 1997). This type of approach starts with the description of the uptake and elimination of a compound by an organism is, as an effect can only be expected if the compound is inside the organism, and where the No Effect Concentration is one of the modeling parameters. As the approach is biologically based it is also possible by using
Dynamic Energy Budgettheory [ [http://www.bio.vu.nl/thb/research/bib/Kooy2000.html Kooijman, 2000] ] to incorporate multiple stressors (e.g. effects of food restriction, temperature [Heugens, 2001, 2003] ), and quite a few processes that are active under field conditions (e.g. adaptation, population dynamics, species interactions, life cycle phenomena [Sibly and Calow (1989)] ). The effects of these multiple stressors are excluded in the standard test procedures by keeping the local environment in the test constant. It is also possible to use these parameter values to predict effects at longer exposure times, or effects when the concentration in the medium is not constant. If the observed effects include those on survival and reproduction of individuals, these parameters can also be used to predict effects on growing populations in the field [Kooijman 1997, Hallam et al 1989] .
*Bruijn J.H.M. and Hof M. (1997) – How to measure no effect. Part IV: how acceptable is the ECx from an environmental policy point of view? Environmetrics, 8: 263 – 267.
*Chen C.W. and Selleck R.E. (1969) - A kinetic model of fish toxicity threshold. Res. J. Water Pollut. Control Feder. 41: 294 – 308.
*Straalen N.M. (1997) – How to measure no effect II: Threshold effects in ecotoxicology. Environmetrics, 8: 249 – 253.
*Crane M. and Newman M.C. (2000) – What level of effect is a no observed effect? Environmental Toxicology and Chemistry, vol 19, no 2, 516 – 519
*Suter G.W. (1996) – Abuse of hypothesis testing statistics in ecological risk assessment, Human and ecological risk assessment 2 (2): 331-347
*Laskowski R. (1995) - Some good reasons to ban the use of NOEC, LOEC and related concepts in ecotoxicology. OIKOS 73:1, pp.140-144
*Hoeven N. van der, Noppert, F. and Leopold A. (1997) – How to measure no effect. Part I: Towards a new measure of chronic toxicity in ecotoxicology. Introduction and workshop results. Environmetrics, 8: 241 – 248.
*OECD, Document No 54 of "Series on Testing Assessment", 2006. Current approaches in the statistical analysis of ecotoxicity data: a guidance to application
*Kooijman S.A.L.M. (1981) - Parametric analyses of mortality rates in bioassays. Water Res. 15: 107 – 119
*T. Jager, Heugens E. H. W. and Kooijman S. A. L. M. (2006) Making sense of ecotoxicological test results: towards process-based models. Ecotoxicology, 15:305-314,
*Péry A.R.R., Flammarion P., Vollat B., Bedaux J.J.M., Kooijman S.A.L.M. and Garric J. (2002) - Using a biology-based model (DEBtox) to analyse bioassays in ecotoxicology: Opportunities & recommendations. Environ. Toxicol. & Chem., 21 (11): 2507-2513
*Kooijman S.A.L.M. (1997) - Process-oriented descriptions of toxic effects. In: Schüürmann, G. and Markert, B. (Eds) Ecotoxicology. Spektrum Akademischer Verlag, 483 - 519
*Kooijman S.A.L.M. (2000) - Dynamic Energy and Mass Budgets in Biological Systems. Cambridge University Press
*Heugens, E. H. W., Hendriks, A. J., Dekker, T., Straalen, N. M. van and Admiraal, W. (2001) - A review of the effects of multiple stressors on aquatic organisms and analysis of uncertainty factors of use in risk assessment. Crit. Rev Toxicol. 31: 247-284
*Heugens, E. H. W., Jager, T., Creyghton, R., Kraak, M. H. S., Hendriks, A. J., Straalen, N. M. van and Admiraal. W. (2003) - Temperature-dependent effects of cadmium on Daphnia magna: accumulation versus sensitivity. Environ. Sci. Tehnol 37: 2145-2151.
*Sibly R.M. and Calow P. (1989)- A life cycle theory of responses to stress. Biological Journal of the Linnean Society 37 (1-2): 101-116
*Hallam T.G., Lassiter R.R. and Kooijman S.A.L.M. (1989) - Effects of toxicants on aquatic populations. In: Levin, S. A., Hallam, T. G. and Gross, L. F. (Eds), Mathematical Ecology. Springer, London: 352 – 382
Wikimedia Foundation. 2010.
Look at other dictionaries:
Predicted No Effect Concentration — Als PNEC (predicited no effect concentration) bezeichnet man die vorausgesagte Konzentration eines in der Regel umweltgefährlichen Stoffes, bis zu der sich keine Auswirkungen auf die Umwelt zeigen. Wird diese Konzentration also unterschritten,… … Deutsch Wikipedia
Concentration effect — During induction of general anesthesia when a large volume of nitrous oxide is taken up from alveoli into pulmonary capillary blood, the concentration of gases remaining in the alveoli is altered. This results in effects known as the… … Wikipedia
Effect of psychoactive drugs on animals — Drugs administered to a spider affect its ability to build a web. … Wikipedia
Concentration of media ownership — Journalism News · Writing style Ethics · Objectivity Values · … Wikipedia
Concentration camps — These camps are distinguished from the death camps, which had as their primary purpose the murder of Jews and other targeted victims of the Nazis. The concentration camps were originally organized to incarcerate political opponents of the Nazi … Historical dictionary of the Holocaust
concentration — con|cen|tra|tion W2S3 [ˌkɔnsənˈtreıʃən US ˌka:n ] n 1.) [U] the ability to think about something carefully or for a long time →↑concentrate ▪ She needed all her powers of concentration to stop herself from slipping on the icy road. ▪ Lack of… … Dictionary of contemporary English
effect — The result or consequence of an action. [L. efficio, pp. effectus, to accomplish, fr. facio, to do] abscopal e. a reaction produced following irradiation but occurring outside the zone of actual radiation absorption. additive e. an e. wherein two … Medical dictionary
concentration effect — koncentracijos ribinė vertė statusas T sritis ekologija ir aplinkotyra apibrėžtis Kenksmingosios cheminės medžiagos koncentracijos žmonių darbo ar gyvenamojoje aplinkoje rodiklis, kurį viršijus cheminės medžiagos poveikis žmonių sveikatai yra… … Ekologijos terminų aiškinamasis žodynas
Measures of pollutant concentration — NOEL redirects here. For other uses, see Noel (disambiguation). Measures of pollutant concentration are used to determine risk assessment in public health. Industry is continually synthesizing new chemicals, the regulation of which requires… … Wikipedia
Measured environmental concentration — An Measured Environmental Concentration (MEC) relates to a chemical substance found in an environmental sample. The concentration of the compound may result from direct contamination, transformation and/or metabolization of an different chemical… … Wikipedia