Desmoglein 2

Desmoglein 2
Identifiers
Symbols	DSG2; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC; MGC117034; MGC117036; MGC117037
External IDs	OMIM: 125671 MGI: 1196466 HomoloGene: 1464 GeneCards: DSG2 Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • plasma membrane • plasma membrane • cell-cell junction • integral to membrane • desmosome Biological process • apoptosis • cellular component disassembly involved in apoptosis • cell adhesion • homophilic cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1829	13511
Ensembl	ENSG00000046604	ENSMUSG00000044393
UniProt	Q14126	n/a
RefSeq (mRNA)	NM_001943.3	NM_007883.2
RefSeq (protein)	NP_001934.2	NP_031909.2
Location (UCSC)	Chr 18: 29.08 – 29.13 Mb	Chr 18: 20.72 – 20.76 Mb
PubMed search	[1]	[2]

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene.^[1][2]

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.^[2]

Interactions

Desmoglein 2 has been shown to interact with DSC1,^[3] Plakoglobin^[4][5][6] and PKP3.^[7]

See also

• Desmoglein

References

1. ^ Arnemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992). "The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18". Genomics 13 (2): 484–6. doi:10.1016/0888-7543(92)90280-6. PMID 1612610. 
2. ^ ^{a b} "Entrez Gene: DSG2 desmoglein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1829. 
3. ^ Chitaev, N A; Troyanovsky S M (Jul. 1997). "Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion". J. Cell Biol. (UNITED STATES) 138 (1): 193–201. doi:10.1083/jcb.138.1.193. ISSN 0021-9525. PMC 2139935. PMID 9214392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139935. 
4. ^ Bannon, L J; Cabrera B L, Stack M S, Green K J (Nov. 2001). "Isoform-specific differences in the size of desmosomal cadherin/catenin complexes". J. Invest. Dermatol. (United States) 117 (5): 1302–6. doi:10.1046/j.1523-1747.2001.01512.x. ISSN 0022-202X. PMID 11710948. 
5. ^ Wahl JK3rd, Jk3rd; Nieset J E, Sacco-Bubulya P A, Sadler T M, Johnson K R, Wheelock M J (May. 2000). "The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2". J. Cell. Sci. (ENGLAND) 113 ( Pt 10): 1737–45. ISSN 0021-9533. PMID 10769205. 
6. ^ Ozawa, M; Terada H, Pedraza C (Nov. 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein". J. Biochem. (JAPAN) 118 (5): 1077–82. ISSN 0021-924X. PMID 8749329. 
7. ^ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMC 2172904. PMID 12707304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172904. 

Further reading

• Koch PJ, Goldschmidt MD, Walsh MJ, et al. (1991). "Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene.". Eur. J. Cell Biol. 55 (2): 200–8. PMID 1935985. 
• Simrak D, Cowley CM, Buxton RS, Arnemann J (1995). "Tandem arrangement of the closely linked desmoglein genes on human chromosome 18.". Genomics 25 (2): 591–4. doi:10.1016/0888-7543(95)80067-V. PMID 7790000. 
• Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins.". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788. 
• Schäfer S, Stumpp S, Franke WW (1996). "Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues.". Differentiation 60 (2): 99–108. doi:10.1046/j.1432-0436.1996.6020099.x. PMID 8641550. 
• Ozawa M, Terada H, Pedraza C (1997). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein.". J. Biochem. 118 (5): 1077–82. PMID 8749329. 
• Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion.". J. Cell Biol. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. PMC 2139935. PMID 9214392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139935. 
• Denning MF, Guy SG, Ellerbroek SM, et al. (1998). "The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C.". Exp. Cell Res. 239 (1): 50–9. doi:10.1006/excr.1997.3890. PMID 9511724. 
• Krunic AL, Garrod DR, Madani S, et al. (1998). "Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin.". Br. J. Cancer 77 (8): 1275–9. doi:10.1038/bjc.1998.213. PMC 2150164. PMID 9579833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150164. 
• Moll I, Houdek P, Schäfer S, et al. (1999). "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model.". Arch. Dermatol. Res. 291 (7-8): 437–46. doi:10.1007/s004030050435. PMID 10482015. 
• Wahl JK3rd , Nieset JE, Sacco-Bubulya PA, et al. (2000). "The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2.". J. Cell. Sci. 113 ( Pt 10): 1737–45. PMID 10769205. 
• Bannon LJ, Cabrera BL, Stack MS, Green KJ (2001). "Isoform-specific differences in the size of desmosomal cadherin/catenin complexes.". J. Invest. Dermatol. 117 (5): 1302–6. doi:10.1046/j.1523-1747.2001.01512.x. PMID 11710948. 
• Chen X, Bonne S, Hatzfeld M, et al. (2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.". J. Biol. Chem. 277 (12): 10512–22. doi:10.1074/jbc.M108765200. PMID 11790773. 
• Syed SE, Trinnaman B, Martin S, et al. (2002). "Molecular interactions between desmosomal cadherins.". Biochem. J. 362 (Pt 2): 317–27. doi:10.1042/0264-6021:3620317. PMC 1222391. PMID 11853539. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222391. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bonné S, Gilbert B, Hatzfeld M, et al. (2003). "Defining desmosomal plakophilin-3 interactions.". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172904. 
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. 
• Wu H, Stanley JR, Cotsarelis G (2003). "Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.". J. Invest. Dermatol. 120 (6): 1052–7. doi:10.1046/j.1523-1747.2003.12234.x. PMID 12787134. 
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Amanchy R, Kalume DE, Iwahori A, et al. (2006). "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).". J. Proteome Res. 4 (5): 1661–71. doi:10.1021/pr050134h. PMID 16212419. 

External links

• GeneReviews/NCBI/NIH/UW entry on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
• OMIM entries on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant