Ergocalciferol


Ergocalciferol
Ergocalciferol
Identifiers
CAS number 50-14-6 YesY
PubChem 5280793
ChemSpider 4444351 YesY
UNII VS041H42XC YesY
DrugBank DB00153
KEGG C05441 YesY
ChEBI CHEBI:28934 YesY
ChEMBL CHEMBL1536 YesY
Jmol-3D images Image 1
Properties
Molecular formula C28H44O
Molar mass 396.65 g/mol
Melting point

114-118 °C

 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ergocalciferol is a form of vitamin D, also called vitamin D2. It is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo) and Calcidol (Patrin Pharma). It is created from viosterol, which in turn is created when ultraviolet light activates ergosterol (which is found in fungi and named as a sterol from ergot) and so comes only from plants.


Ergocalciferol is widely used as a Vitamin D supplement, and a 2011 clinical guideline[1] considers it to be as effective as cholecalciferol (Vitamin D3), which is produced naturally by the skin when it is exposed to ultraviolet light. However there is now conflicting evidence regarding how similarly D2 and D3 behave in the body and whether they are equally potent. Some studies suggest D3 is more potent[2][3], but others have found that they are equally effective[4][5].


References

  1. ^ Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline". Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. doi:10.1210/jc.2011-0385. PMID 21646368.  edit
  2. ^ Houghton, L.; Vieth, R. (2006). "The case against ergocalciferol (vitamin D2) as a vitamin supplement". The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.  edit
  3. ^ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2". The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.  edit
  4. ^ Holick, M. F.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. et al. (2007). "Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D". Journal of Clinical Endocrinology & Metabolism 93 (3): 677. doi:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2266966.  edit
  5. ^ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. et al. (2010). "Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults". American Journal of Clinical Nutrition 91 (6): 1621–1626. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2869510.  edit


External links



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Look at other dictionaries:

  • Ergocalciférol — Général Nom IUPAC (3β,5Z,7E,22E) 9,10 sécoergosta 5,7,10(19),22 tetraén 3 ol Synonymes …   Wikipédia en Français

  • ergocalciferol — ERGOCALCIFERÓL s.m. Vitamina D2. – Denumire comercială. Trimis de LauraGellner, 13.06.2004. Sursa: DEX 98  ERGOCALCIFERÓL s. v. vitamina D2. Trimis de siveco, 05.08.2004. Sursa: Sinonime  ergocalciferól s. m. Trimis de siveco, 10.08.2004. Sursa …   Dicționar Român

  • ergocalciferol — n. vitamin D2, one of the D vitamins, a group of related substances that prevent rickets. Syn: vitamin D, calciferol, cholecarciferol, D. [WordNet 1.5 +PJC] …   The Collaborative International Dictionary of English

  • ergocalciferol — Véase calciferol. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • ergocalciferol — [ʉr΄gō kal sif′ər ôl΄, ʉr΄gō kas sif′ərōl΄] n. a crystalline sterol, C28H43OH, formed by the ultraviolet irradiation of ergosterol; vitamin D2 * * * er·go·cal·cif·er·ol (ûr gō kăl sĭfʹə rôl , rōl ) n. See vitamin D2.   [ergot + calciferol.] * * * …   Universalium

  • ergocalciférol — ● ergocalciférol nom masculin Calciférol …   Encyclopédie Universelle

  • ergocalciferol — [ʉr΄gō kal sif′ər ôl΄, ʉr΄gō kas sif′ərōl΄] n. a crystalline sterol, C28H43OH, formed by the ultraviolet irradiation of ergosterol; vitamin D2 …   English World dictionary

  • Ergocalciferol — Strukturformel Allgemeines Name Ergocalciferol Andere Namen …   Deutsch Wikipedia

  • ergocalciferol — Activated ergosterol, the vitamin D of plant origin; it arises from ultraviolet irradiation of ergosterol, which is cleaved at the 9,10 bond and develops a double bond between C 10 and C 19; used in prophylaxis and treatment of vitamin D …   Medical dictionary

  • Ergocalciferol — Er|go|cal|ci|fe|rol [↑ Ergo ] ↑ Calciferol. * * * Ergocalciferol,   das Vitamin D2 (Calciferole) …   Universal-Lexikon


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