Corticosterone


Corticosterone
Corticosterone
Identifiers
CAS number 50-22-6 YesY
PubChem 5753
ChemSpider 5550 YesY
UNII W980KJ009P N
DrugBank DB04652
MeSH Corticosterone
ChEBI CHEBI:16827 N
ChEMBL CHEMBL110739 N
Jmol-3D images Image 1
Properties
Molecular formula C21H30O4
Molar mass 346.46 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Corticosterone (CORT) is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.

Contents

Roles

In many species, including amphibians, reptiles, rodents and birds, corticosterone is a main glucocorticoid,[1] involved in regulation of fuel, immune reactions, and stress responses.

However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.

Release or generation mechanisms

One example of a release pathway relates to UV-B stimulation on the skins of certain amphibians such as the Rough-skinned Newt, Taricha granulosa; this trigger seems to cause the internal generation of corticosterone in that species.[2]

References

  1. ^ "e.hormone | The Hormones : Corticoids". http://e.hormone.tulane.edu/learning/corticoids.html. Retrieved 2009-04-09. 
  2. ^ C. Michael Hogan (2008) Rough-skinned Newt (Taricha granulosa), Globaltwitcher, ed. Nicklas Stromberg [1]

Additional images


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Look at other dictionaries:

  • corticosterone — n. any of several steroid compounds secreted by the adrenal cortex; they are involved in regulating water and electrolyte balance in the body. [WordNet 1.5] …   The Collaborative International Dictionary of English

  • Corticosterone — Corticostérone La corticostérone est une hormone corticostéroïde secrétée par le cortex (écorce) de la glande surrénale à partir du cholestérol et sous la dépendance de l ACTH hypophysaire. Portail de la médecine Ce document provient de «… …   Wikipédia en Français

  • corticostérone — ● corticostérone nom féminin Hormone du groupe des glucocorticoïdes sécrétée par la corticosurrénale …   Encyclopédie Universelle

  • corticosterone — [kôr΄ti kō΄stir′ōn΄, kôr΄tikäs′tə rōn΄] n. [ CORTICO + STER(OL) + ONE] a corticosteroid, C21H30O4, that aids muscle efficiency, carbohydrate metabolism, etc …   English World dictionary

  • Corticostérone — La corticostérone est une hormone corticostéroïde secrétée par le cortex (écorce) de la glande surrénale à partir du cholestérol et sous la dépendance de l ACTH hypophysaire. Portail de la médecine …   Wikipédia en Français

  • corticosterone — noun Date: 1937 a colorless crystalline corticosteroid C21H30O4 that is important in protein and carbohydrate metabolism …   New Collegiate Dictionary

  • corticosterone — /kawr ti kos teuh rohn , koh steuh rohn /, n. Biochem. a steroid hormone, secreted by the adrenal cortex, that is involved in regulation of the water and electrolyte balance of the body. [1935 40; CORTICO + STER(OL) + ONE] * * * …   Universalium

  • corticosterone — noun A corticosteroid hormone, produced in the adrenal glands, involved in metabolism …   Wiktionary

  • corticosterone — A corticosteroid that induces some deposition of glycogen in the liver, sodium conservation, and potassium excretion; the principal glucocortoid in the rat. * * * cor·ti·co·ste·rone .kȯrt ə käs tə .rōn, i kō stə ; .kȯrt i kō sti(ə)r .ōn,… …   Medical dictionary

  • corticosterone — cor·ti·co·ste·ró·ne s.m. TS biochim. steroide corticosurrenale, con attività sul metabolismo glicidico e sul tono dei vasi sanguigni {{line}} {{/line}} DATA: 1956. ETIMO: der. di cortico e ster(olo) con 2 one …   Dizionario italiano


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